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Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy.

Publication ,  Journal Article
Davis, EM; Ewald, G; Givertz, MM; Rajagopalan, N; Cooper, LT; Briller, J; Felker, GM; Bozkurt, B; Drazner, MH; Hanley-Yanez, K; Halder, I ...
Published in: Am J Perinatol
April 2019

OBJECTIVE: To examine the association between maternal obesity on left ventricular (LV) size and recovery in women with peripartum cardiomyopathy (PPCM). STUDY DESIGN: This was a prospective analysis of 100 women enrolled within 13 weeks of PPCM diagnosis and followed for a year in the Investigation of Pregnancy Associated Cardiomyopathy study. Adiposity was defined by standard body mass index (BMI) definitions for under/normal weight, overweight, and obesity. Demographic, clinical, and biomarker variables were compared across weight categories. OUTCOMES: LV end-diastolic diameter (LVEDD) and ejection fraction were measured at entry, 6, and 12 months postpartum. Multivariable regression models examined the relationship between adiposity, LV size, and leptin levels with cardiac recovery at 6 and 12 months postpartum. RESULTS: Obese and nonobese women had similar LV dysfunction at entry. Obese women had greater LV size and less LV recovery at 6 and 12 months postpartum. BMI was positively associated with leptin and ventricular diameter. Greater BMI at entry remained associated with less ventricular recovery at 6 months (p = 0.02) in adjusted race-stratified models. LVEDD at entry predicted lower ejection fraction at 6 months (p < 0.001) and similarly at 12 months. CONCLUSION: Obese women with PPCM had greater cardiac remodeling, higher leptin levels, and diminished cardiac recovery.

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Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

April 2019

Volume

36

Issue

5

Start / End Page

476 / 483

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Remodeling
  • Ventricular Function, Left
  • Stroke Volume
  • Prospective Studies
  • Pregnancy Complications, Cardiovascular
  • Pregnancy
  • Peripartum Period
  • Obstetrics & Reproductive Medicine
  • Obesity, Maternal
 

Citation

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Chicago
ICMJE
MLA
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Davis, E. M., Ewald, G., Givertz, M. M., Rajagopalan, N., Cooper, L. T., Briller, J., … IPAC Investigators, . (2019). Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy. Am J Perinatol, 36(5), 476–483. https://doi.org/10.1055/s-0038-1669439
Davis, Esa M., Gregory Ewald, Michael M. Givertz, Navin Rajagopalan, Leslie T. Cooper, Joan Briller, G Michael Felker, et al. “Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy.Am J Perinatol 36, no. 5 (April 2019): 476–83. https://doi.org/10.1055/s-0038-1669439.
Davis EM, Ewald G, Givertz MM, Rajagopalan N, Cooper LT, Briller J, et al. Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy. Am J Perinatol. 2019 Apr;36(5):476–83.
Davis, Esa M., et al. “Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy.Am J Perinatol, vol. 36, no. 5, Apr. 2019, pp. 476–83. Pubmed, doi:10.1055/s-0038-1669439.
Davis EM, Ewald G, Givertz MM, Rajagopalan N, Cooper LT, Briller J, Felker GM, Bozkurt B, Drazner MH, Hanley-Yanez K, Halder I, McTiernan CF, McNamara DM, IPAC Investigators. Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy. Am J Perinatol. 2019 Apr;36(5):476–483.
Journal cover image

Published In

Am J Perinatol

DOI

EISSN

1098-8785

Publication Date

April 2019

Volume

36

Issue

5

Start / End Page

476 / 483

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Remodeling
  • Ventricular Function, Left
  • Stroke Volume
  • Prospective Studies
  • Pregnancy Complications, Cardiovascular
  • Pregnancy
  • Peripartum Period
  • Obstetrics & Reproductive Medicine
  • Obesity, Maternal