Separate Primary Melanomas of the Bulbar Conjunctiva and Eyelid Skin: Clinical Implications of Multiple Primary Melanomas


Journal Article

© 2016 S. Karger AG, Basel. Purpose: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. Methods: This article offers a clinicopathological correlation with a review of the relevant literature. Results: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion. Excisional biopsies revealed that both were primary melanomas arising within in situ disease. Over the span of 25 years, the patient had three separate foci of in situ melanoma, two of which spawned invasive melanoma. Conclusion: Separate melanomas arising from the bulbar conjunctiva and eyelid skin have rarely been reported. Multiple primary melanomas of the skin, however, are not uncommon. Based on studies of persons with multiple cutaneous melanomas, the prognosis is best predicted by the tumor with the greatest depth of invasion. Patients with multiple melanomas should be examined for dysplastic nevi, additional cutaneous melanomas, and screened periodically for future lesions. Ongoing studies enrolling patients with multiple primary melanomas are attempting to generate insights into low-penetrance susceptibility genes.

Full Text

Duke Authors

Cited Authors

  • Jacinto, FA; Fisher, GH; Espana, EM; Leyngold, IM; Margo, CE

Published Date

  • October 1, 2016

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 226 - 229

Electronic International Standard Serial Number (EISSN)

  • 2296-4657

International Standard Serial Number (ISSN)

  • 2296-4681

Digital Object Identifier (DOI)

  • 10.1159/000445543

Citation Source

  • Scopus