Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study.

Journal Article (Journal Article;Multicenter Study)

Acute lymphoblastic leukemia (ALL) in infants <1-year-old is biologically different from ALL in older children. Although KMT2A rearrangement is the predominant genetic signature in infantile B-ALL, disease course is heterogenous, behaving more aggressively in younger infants. We investigated clinicopathological differences throughout the first year to understand the transition to pediatric B-ALL. In a multi-institutional review involving four medical institutions, 54 cases of infantile B-ALL were identified. Patients were divided into congenital and non-congenital groups with multiple age subgroups. Male predominance was seen in congenital cases compared to female in non-congenital cases. There were decreasing trends of hyperleukocytosis, central nervous system involvement, KMT2A rearrangements, lineage switch, and mortality, versus increasing trends of CD10 expression and non-KMT2A abnormalities. Statistically significant differences emerged at 3 and 9 months, the latter was not previously described. Poor-prognostic risk factors decreased with age, the last trimester of infantile B-ALL essentially merging with pediatric B-ALL.

Full Text

Duke Authors

Cited Authors

  • Knez, V; Liu, X; Schowinsky, J; Pan, Z; Wang, D; Lorsbach, R; Lu, C; Luedke, C; Haag, M; Carstens, B; Swisshelm, K; Yang, L-H; Jug, R; Wang, E; Liang, X

Published Date

  • April 2019

Published In

Volume / Issue

  • 60 / 4

Start / End Page

  • 1006 - 1013

PubMed ID

  • 30188223

Electronic International Standard Serial Number (EISSN)

  • 1029-2403

Digital Object Identifier (DOI)

  • 10.1080/10428194.2018.1508667


  • eng

Conference Location

  • United States