Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity?
Publication
, Journal Article
Lassinger, BK; Kwak, C; Walford, RL; Jankovic, J
Published in: Mov Disord
April 2004
Exogenous toxins and chronic hypoxia have been implicated in the etiopathogenesis of a variety of neurological disorders, but it is not always possible to establish a cause-effect relationships. We describe a patient who presented with an unusual gait disorder and progressive motor neuron disease after residing for 2 years within Biosphere 2, a scientifically engineered dome, tightly sealed to allow miniscule exchange of air between its atmosphere and the earth's atmosphere. We postulate that this unusual syndrome resulted from chronic hypoxia possibly coupled with carbon monoxide and nitrous oxide exposure.
Duke Scholars
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Published In
Mov Disord
DOI
ISSN
0885-3185
Publication Date
April 2004
Volume
19
Issue
4
Start / End Page
465 / 469
Location
United States
Related Subject Headings
- Spinal Osteophytosis
- Severity of Illness Index
- Parkinsonian Disorders
- Oxygen Consumption
- Nitrous Oxide
- Neurology & Neurosurgery
- Neck
- Motor Neuron Disease
- Male
- Magnetic Resonance Imaging
Citation
APA
Chicago
ICMJE
MLA
NLM
Lassinger, B. K., Kwak, C., Walford, R. L., & Jankovic, J. (2004). Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity? Mov Disord, 19(4), 465–469. https://doi.org/10.1002/mds.20076
Lassinger, Brian K., Carolyn Kwak, Roy L. Walford, and Joseph Jankovic. “Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity?” Mov Disord 19, no. 4 (April 2004): 465–69. https://doi.org/10.1002/mds.20076.
Lassinger BK, Kwak C, Walford RL, Jankovic J. Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity? Mov Disord. 2004 Apr;19(4):465–9.
Lassinger, Brian K., et al. “Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity?” Mov Disord, vol. 19, no. 4, Apr. 2004, pp. 465–69. Pubmed, doi:10.1002/mds.20076.
Lassinger BK, Kwak C, Walford RL, Jankovic J. Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity? Mov Disord. 2004 Apr;19(4):465–469.
Published In
Mov Disord
DOI
ISSN
0885-3185
Publication Date
April 2004
Volume
19
Issue
4
Start / End Page
465 / 469
Location
United States
Related Subject Headings
- Spinal Osteophytosis
- Severity of Illness Index
- Parkinsonian Disorders
- Oxygen Consumption
- Nitrous Oxide
- Neurology & Neurosurgery
- Neck
- Motor Neuron Disease
- Male
- Magnetic Resonance Imaging