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Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review.

Publication ,  Journal Article
Penn, DL; Tartarini, RJ; Glass, CH; De Girolami, U; Zamani, AA; Dunn, IF
Published in: Surg Neurol Int
2017

BACKGROUND: Fibrous dysplasia (FD) is a rare developmental disease characterized by the replacement of bone marrow with proliferating fibro-osseous tissue. There exist three forms of FD-monostotic, polyostotic, and that associated with McCune-Albright syndrome. The disease can present in different locations and with a variety of symptoms. One of the more common locations of FD occurrence is the craniofacial region. Treatment of asymptomatic FD often involves conservative management with serial imaging. Medical management with bisphosphonates is an option, though long-term efficacy data are lacking. Surgical resection is usually reserved for very large or symptomatic lesions. CASE DESCRIPTION: We discuss the most unusual case of a 52-year-old male found to have a left pterional mass while being worked up for sinus headaches. The patient elected to follow this lesion conservatively, and imaging several years later showed obvious growth which accelerated in the last 4 years during an 18-year observational period. He ultimately underwent successful resection of an extradural and intradural FD. CONCLUSIONS: The significant growth potential of these lesions was revealed in this patient, in whom conservative management had been adopted. Despite optimal surgical resection and outcome in this case, the importance of surveillance imaging and perhaps earlier intervention cannot be underestimated when managing cranial FD.

Duke Scholars

Published In

Surg Neurol Int

DOI

ISSN

2229-5097

Publication Date

2017

Volume

8

Start / End Page

209

Location

United States

Related Subject Headings

  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Penn, D. L., Tartarini, R. J., Glass, C. H., De Girolami, U., Zamani, A. A., & Dunn, I. F. (2017). Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review. Surg Neurol Int, 8, 209. https://doi.org/10.4103/sni.sni_7_17
Penn, David L., Richard J. Tartarini, Carolyn H. Glass, Umberto De Girolami, Amir A. Zamani, and Ian F. Dunn. “Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review.Surg Neurol Int 8 (2017): 209. https://doi.org/10.4103/sni.sni_7_17.
Penn DL, Tartarini RJ, Glass CH, De Girolami U, Zamani AA, Dunn IF. Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review. Surg Neurol Int. 2017;8:209.
Penn, David L., et al. “Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review.Surg Neurol Int, vol. 8, 2017, p. 209. Pubmed, doi:10.4103/sni.sni_7_17.
Penn DL, Tartarini RJ, Glass CH, De Girolami U, Zamani AA, Dunn IF. Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review. Surg Neurol Int. 2017;8:209.

Published In

Surg Neurol Int

DOI

ISSN

2229-5097

Publication Date

2017

Volume

8

Start / End Page

209

Location

United States

Related Subject Headings

  • 1109 Neurosciences
  • 1103 Clinical Sciences