Neurosurgical applications of fibrin glue: augmentation of dural closure in 134 patients.

Journal Article (Journal Article)

In a wide variety of neurosurgical procedures performed on 134 patients over a 3-year period, fibrin glue has been applied as an adjunct to dural closure. Overall success at preventing cerebrospinal fluid (CSF) leakage was 90% (121 of 134, 90% effective). In patients considered to be at high risk for CSF leakage intraoperatively but without pre-established fistulae (Group 1), the success rate was higher (111 of 119, 93% effective). In patients with pre-established CSF fistulae (Group 2), the success rate was lower (10 of 15, 67% effective). As single donor sources of concentrated fibrinogen are now available with reduced risks of blood-borne disease transmission, fibrin glue may be a valuable clinical tool for the neurosurgeon.

Full Text

Duke Authors

Cited Authors

  • Shaffrey, CI; Spotnitz, WD; Shaffrey, ME; Jane, JA

Published Date

  • February 1990

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 207 - 210

PubMed ID

  • 2308667

International Standard Serial Number (ISSN)

  • 0148-396X


  • eng

Conference Location

  • United States