The association of lumbar spondylolisthesis with collagen IX tryptophan alleles.

Journal Article (Journal Article)

Two collagen type IX gene polymorphisms that introduce a tryptophan residue into the protein's triple-helical domain have been linked to an increased risk of lumbar disc disease. To determine whether a particular subset of symptomatic lumbar disease is specifically associated with these polymorphisms, we performed a prospective case-control study of 107 patients who underwent surgery of the lumbar spine. Patients were assigned to one of five clinical categories (fracture, disc degeneration, disc herniation, spinal stenosis without spondylolisthesis and spinal stenosis with spondylolisthesis) based on history, imaging results, and findings during surgery. Of the 11 tryptophan-positive patients, eight had spinal stenosis with spondylolisthesis and three had disc herniation. The presence of the tryptophan allele was significantly associated with African-American or Asian designation for race (odds ratio 4.61, 95% CI 0.63 to 25.35) and with the diagnosis of spinal stenosis with spondylolisthesis (odds ratio 6.81, 95% CI 1.47 to 41.95). Our findings indicate that tryptophan polymorphisms predispose carriers to the development of symptomatic spinal stenosis associated with spondylolisthesis which requires surgery.

Full Text

Duke Authors

Cited Authors

  • Matsui, Y; Mirza, SK; Wu, JJ; Carter, B; Bellabarba, C; Shaffrey, CI; Chapman, JR; Eyre, DR

Published Date

  • September 2004

Published In

Volume / Issue

  • 86 / 7

Start / End Page

  • 1021 - 1026

PubMed ID

  • 15446531

International Standard Serial Number (ISSN)

  • 0301-620X

Digital Object Identifier (DOI)

  • 10.1302/0301-620x.86b7.14994


  • eng

Conference Location

  • England