Feather development genes and associated regulatory innovation predate the origin of Dinosauria.

Published

Journal Article

The evolution of avian feathers has recently been illuminated by fossils and the identification of genes involved in feather patterning and morphogenesis. However, molecular studies have focused mainly on protein-coding genes. Using comparative genomics and more than 600,000 conserved regulatory elements, we show that patterns of genome evolution in the vicinity of feather genes are consistent with a major role for regulatory innovation in the evolution of feathers. Rates of innovation at feather regulatory elements exhibit an extended period of innovation with peaks in the ancestors of amniotes and archosaurs. We estimate that 86% of such regulatory elements and 100% of the nonkeratin feather gene set were present prior to the origin of Dinosauria. On the branch leading to modern birds, we detect a strong signal of regulatory innovation near insulin-like growth factor binding protein (IGFBP) 2 and IGFBP5, which have roles in body size reduction, and may represent a genomic signature for the miniaturization of dinosaurian body size preceding the origin of flight.

Full Text

Duke Authors

Cited Authors

  • Lowe, CB; Clarke, JA; Baker, AJ; Haussler, D; Edwards, SV

Published Date

  • January 2015

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 23 - 28

PubMed ID

  • 25415961

Pubmed Central ID

  • 25415961

Electronic International Standard Serial Number (EISSN)

  • 1537-1719

Digital Object Identifier (DOI)

  • 10.1093/molbev/msu309

Language

  • eng

Conference Location

  • United States