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Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex.

Publication ,  Journal Article
Vaz, AP; Yaffe, RB; Wittig, JH; Inati, SK; Zaghloul, KA
Published in: Neuroimage
March 1, 2017

Phase-amplitude coupling (PAC) is hypothesized to coordinate neural activity, but its role in successful memory formation in the human cortex is unknown. Measures of PAC are difficult to interpret, however. Both increases and decreases in PAC have been linked to memory encoding, and PAC may arise due to different neural mechanisms. Here, we use a waveform analysis to examine PAC in the human cortex as participants with intracranial electrodes performed a paired associates memory task. We found that successful memory formation exhibited significant decreases in left temporal lobe and prefrontal cortical PAC, and these two regions exhibited changes in PAC within different frequency bands. Two underlying neural mechanisms, nested oscillations and sharp waveforms, were responsible for the changes in these regions. Our data therefore suggest that decreases in measured cortical PAC during episodic memory reflect two distinct underlying mechanisms that are anatomically segregated in the human brain.

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Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

March 1, 2017

Volume

148

Start / End Page

148 / 159

Location

United States

Related Subject Headings

  • Wavelet Analysis
  • Psychomotor Performance
  • Neurology & Neurosurgery
  • Memory, Episodic
  • Male
  • Humans
  • Female
  • Entropy
  • Electroencephalography
  • Electrodes, Implanted
 

Citation

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MLA
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Vaz, A. P., Yaffe, R. B., Wittig, J. H., Inati, S. K., & Zaghloul, K. A. (2017). Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex. Neuroimage, 148, 148–159. https://doi.org/10.1016/j.neuroimage.2017.01.001
Vaz, Alex P., Robert B. Yaffe, John H. Wittig, Sara K. Inati, and Kareem A. Zaghloul. “Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex.Neuroimage 148 (March 1, 2017): 148–59. https://doi.org/10.1016/j.neuroimage.2017.01.001.
Vaz AP, Yaffe RB, Wittig JH, Inati SK, Zaghloul KA. Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex. Neuroimage. 2017 Mar 1;148:148–59.
Vaz, Alex P., et al. “Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex.Neuroimage, vol. 148, Mar. 2017, pp. 148–59. Pubmed, doi:10.1016/j.neuroimage.2017.01.001.
Vaz AP, Yaffe RB, Wittig JH, Inati SK, Zaghloul KA. Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex. Neuroimage. 2017 Mar 1;148:148–159.
Journal cover image

Published In

Neuroimage

DOI

EISSN

1095-9572

Publication Date

March 1, 2017

Volume

148

Start / End Page

148 / 159

Location

United States

Related Subject Headings

  • Wavelet Analysis
  • Psychomotor Performance
  • Neurology & Neurosurgery
  • Memory, Episodic
  • Male
  • Humans
  • Female
  • Entropy
  • Electroencephalography
  • Electrodes, Implanted