Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy.

Published

Journal Article (Review)

The objective of this study was to determine whether disagreements among multiple data sources affect systematic reviews of randomized clinical trials (RCTs).Eligible RCTs examined gabapentin for neuropathic pain and quetiapine for bipolar depression, reported in public (e.g., journal articles) and nonpublic sources (clinical study reports [CSRs] and individual participant data [IPD]).We found 21 gabapentin RCTs (74 reports, 6 IPD) and 7 quetiapine RCTs (50 reports, 1 IPD); most were reported in journal articles (18/21 [86%] and 6/7 [86%], respectively). When available, CSRs contained the most trial design and risk of bias information. CSRs and IPD contained the most results. For the outcome domains "pain intensity" (gabapentin) and "depression" (quetiapine), we found single trials with 68 and 98 different meta-analyzable results, respectively; by purposefully selecting one meta-analyzable result for each RCT, we could change the overall result for pain intensity from effective (standardized mean difference [SMD] = -0.45; 95% confidence interval [CI]: -0.63 to -0.27) to ineffective (SMD = -0.06; 95% CI: -0.24 to 0.12). We could change the effect for depression from a medium effect (SMD = -0.55; 95% CI: -0.85 to -0.25) to a small effect (SMD = -0.26; 95% CI: -0.41 to -0.1).Disagreements across data sources affect the effect size, statistical significance, and interpretation of trials and meta-analyses.

Full Text

Duke Authors

Cited Authors

  • Mayo-Wilson, E; Li, T; Fusco, N; Bertizzolo, L; Canner, JK; Cowley, T; Doshi, P; Ehmsen, J; Gresham, G; Guo, N; Haythornthwaite, JA; Heyward, J; Hong, H; Pham, D; Payne, JL; Rosman, L; Stuart, EA; Suarez-Cuervo, C; Tolbert, E; Twose, C; Vedula, S; Dickersin, K

Published Date

  • November 2017

Published In

Volume / Issue

  • 91 /

Start / End Page

  • 95 - 110

PubMed ID

  • 28842290

Pubmed Central ID

  • 28842290

Electronic International Standard Serial Number (EISSN)

  • 1878-5921

International Standard Serial Number (ISSN)

  • 0895-4356

Digital Object Identifier (DOI)

  • 10.1016/j.jclinepi.2017.07.014

Language

  • eng