Precision Medicine Approaches When Prostate Cancer Akts Up.
Publication
, Journal Article
Zhang, T; George, DJ; Armstrong, AJ
Published in: Clin Cancer Res
February 1, 2019
Ipatasertib combined with abiraterone in PTEN-null prostate cancer improved progression-free survival in a randomized phase II study of patients with metastatic castration-resistant prostate cancer (mCRPC), providing clinical evidence of reciprocal activation between the Akt and androgen receptor (AR) pathways. These data revive the rationale for targeting PTEN loss in prostate cancer.See related article by de Bono et al., p. 928.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Clin Cancer Res
DOI
EISSN
1557-3265
Publication Date
February 1, 2019
Volume
25
Issue
3
Start / End Page
901 / 903
Location
United States
Related Subject Headings
- Receptors, Androgen
- Proto-Oncogene Proteins c-akt
- Prostatic Neoplasms, Castration-Resistant
- Prostate-Specific Antigen
- Precision Medicine
- PTEN Phosphohydrolase
- Oncology & Carcinogenesis
- Male
- Humans
- Androstenes
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, T., George, D. J., & Armstrong, A. J. (2019). Precision Medicine Approaches When Prostate Cancer Akts Up. Clin Cancer Res, 25(3), 901–903. https://doi.org/10.1158/1078-0432.CCR-18-2491
Zhang, Tian, Daniel J. George, and Andrew J. Armstrong. “Precision Medicine Approaches When Prostate Cancer Akts Up.” Clin Cancer Res 25, no. 3 (February 1, 2019): 901–3. https://doi.org/10.1158/1078-0432.CCR-18-2491.
Zhang T, George DJ, Armstrong AJ. Precision Medicine Approaches When Prostate Cancer Akts Up. Clin Cancer Res. 2019 Feb 1;25(3):901–3.
Zhang, Tian, et al. “Precision Medicine Approaches When Prostate Cancer Akts Up.” Clin Cancer Res, vol. 25, no. 3, Feb. 2019, pp. 901–03. Pubmed, doi:10.1158/1078-0432.CCR-18-2491.
Zhang T, George DJ, Armstrong AJ. Precision Medicine Approaches When Prostate Cancer Akts Up. Clin Cancer Res. 2019 Feb 1;25(3):901–903.
Published In
Clin Cancer Res
DOI
EISSN
1557-3265
Publication Date
February 1, 2019
Volume
25
Issue
3
Start / End Page
901 / 903
Location
United States
Related Subject Headings
- Receptors, Androgen
- Proto-Oncogene Proteins c-akt
- Prostatic Neoplasms, Castration-Resistant
- Prostate-Specific Antigen
- Precision Medicine
- PTEN Phosphohydrolase
- Oncology & Carcinogenesis
- Male
- Humans
- Androstenes