The importance of preclinical diagnostics in Parkinson disease.

Journal Article (Journal Article;Review)

Given the increasing recognition that neurodegeneration begins decades before the appearance of motor symptoms of Parkinson disease (PD), recent attention has turned to methods of preclinical or prodromal diagnosis. Accurate preclinical diagnosis of individuals at high risk of developing manifest motor PD can improve clinical counseling as well as provide an enriched cohort for studies of possible disease-modifying therapies. In this review article, the authors synthesize the myriad clinical, radiographic, and biochemical signatures of preclinical PD, with an emphasis on biomarkers that may provide accurate population screening for the disease. As individual biomarkers have relatively lowsensitivity and specificity, any population-based approach to preclinical diagnosis will likely combine multiple biomarkers to improve both negative and positive predictive value.

Full Text

Duke Authors

Cited Authors

  • Mantri, S; Morley, JF; Siderowf, AD

Published Date

  • July 2019

Published In

Volume / Issue

  • 64 /

Start / End Page

  • 20 - 28

PubMed ID

  • 30224266

Electronic International Standard Serial Number (EISSN)

  • 1873-5126

Digital Object Identifier (DOI)

  • 10.1016/j.parkreldis.2018.09.011


  • eng

Conference Location

  • England