Where We Stand With Immunotherapy in Colorectal Cancer: Deficient Mismatch Repair, Proficient Mismatch Repair, and Toxicity Management.

Journal Article (Journal Article;Review)

With the recent U.S. Food and Drug Administration approvals of pembrolizumab and nivolumab for refractory deficient mismatch repair metastatic colorectal cancer, immune checkpoint inhibitors have now entered into clinical care for gastrointestinal cancers. Extensive ongoing efforts are exploring additional combinations of therapy in both deficient and proficient mismatch repair colorectal cancer. This review will outline the current status of such efforts and discuss the critical aspects of recognition and management of immune-related toxicities from checkpoint inhibitors.

Full Text

Duke Authors

Cited Authors

  • Overman, MJ; Ernstoff, MS; Morse, MA

Published Date

  • May 23, 2018

Published In

Volume / Issue

  • 38 /

Start / End Page

  • 239 - 247

PubMed ID

  • 30231358

Electronic International Standard Serial Number (EISSN)

  • 1548-8756

Digital Object Identifier (DOI)

  • 10.1200/EDBK_200821


  • eng

Conference Location

  • United States