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Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy.

Publication ,  Journal Article
Vienneau, E; Liu, W; Yao, J
Published in: Optics letters
September 2018

Acoustic-resolution photoacoustic microscopy (AR-PAM) can provide penetration depths beyond the optical diffusion limit, but its lateral resolution is typically much worse than its axial resolution, resulting in a low-resolution isotropy. We herein present a dual-view AR-PAM (DV-AR-PAM) system that exploits two orthogonally arranged focused ultrasonic transducers. Taking advantage of their complementary acoustic detecting profiles, DV-AR-PAM allows the fusion of the dual-view signals, resulting in an enhancement in the resolution isotropy from 29% to 95% within one imaging plane, as demonstrated by simulation results on densely packed particles and experimental results on a single carbon fiber. The application of this method in vivo revealed distinct microvasculature structures in mouse skin that were previously indistinguishable with single-view detection, demonstrating the potential of DV-AR-PAM for vascular and neurological studies.

Duke Scholars

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

September 2018

Volume

43

Issue

18

Start / End Page

4413 / 4416

Related Subject Headings

  • Signal-To-Noise Ratio
  • Photoacoustic Techniques
  • Optics
  • Microscopy
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
  • 0906 Electrical and Electronic Engineering
  • 0206 Quantum Physics
  • 0205 Optical Physics
 

Citation

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Vienneau, E., Liu, W., & Yao, J. (2018). Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy. Optics Letters, 43(18), 4413–4416. https://doi.org/10.1364/ol.43.004413
Vienneau, Emelina, Wei Liu, and Junjie Yao. “Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy.Optics Letters 43, no. 18 (September 2018): 4413–16. https://doi.org/10.1364/ol.43.004413.
Vienneau E, Liu W, Yao J. Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy. Optics letters. 2018 Sep;43(18):4413–6.
Vienneau, Emelina, et al. “Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy.Optics Letters, vol. 43, no. 18, Sept. 2018, pp. 4413–16. Epmc, doi:10.1364/ol.43.004413.
Vienneau E, Liu W, Yao J. Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy. Optics letters. 2018 Sep;43(18):4413–4416.
Journal cover image

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

September 2018

Volume

43

Issue

18

Start / End Page

4413 / 4416

Related Subject Headings

  • Signal-To-Noise Ratio
  • Photoacoustic Techniques
  • Optics
  • Microscopy
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
  • 0906 Electrical and Electronic Engineering
  • 0206 Quantum Physics
  • 0205 Optical Physics