Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy.

Published

Journal Article

Acoustic-resolution photoacoustic microscopy (AR-PAM) can provide penetration depths beyond the optical diffusion limit, but its lateral resolution is typically much worse than its axial resolution, resulting in a low-resolution isotropy. We herein present a dual-view AR-PAM (DV-AR-PAM) system that exploits two orthogonally arranged focused ultrasonic transducers. Taking advantage of their complementary acoustic detecting profiles, DV-AR-PAM allows the fusion of the dual-view signals, resulting in an enhancement in the resolution isotropy from 29% to 95% within one imaging plane, as demonstrated by simulation results on densely packed particles and experimental results on a single carbon fiber. The application of this method in vivo revealed distinct microvasculature structures in mouse skin that were previously indistinguishable with single-view detection, demonstrating the potential of DV-AR-PAM for vascular and neurological studies.

Full Text

Duke Authors

Cited Authors

  • Vienneau, E; Liu, W; Yao, J

Published Date

  • September 2018

Published In

Volume / Issue

  • 43 / 18

Start / End Page

  • 4413 - 4416

PubMed ID

  • 30211878

Pubmed Central ID

  • 30211878

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.43.004413

Language

  • eng