Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells.

Published

Journal Article

Direction-selective ganglion cells (DSGCs) deliver signals from the retina to multiple brain areas to indicate the presence and direction of motion. Delivering reliable signals in response to motion is critical across light levels. Here we determine how populations of DSGCs adapt to changes in light level, from moonlight to daylight. Using large-scale measurements of neural activity, we demonstrate that the population of DSGCs switches encoding strategies across light levels. Specifically, the direction tuning of superior (upward)-preferring ON-OFF DSGCs becomes broader at low light levels, whereas other DSGCs exhibit stable tuning. Using a conditional knockout of gap junctions, we show that this differential adaptation among superior-preferring ON-OFF DSGCs is caused by connexin36-mediated electrical coupling and differences in effective GABAergic inhibition. Furthermore, this adaptation strategy is beneficial for balancing motion detection and direction estimation at the lower signal-to-noise ratio encountered at night. These results provide insights into how light adaptation impacts motion encoding in the retina.

Full Text

Duke Authors

Cited Authors

  • Yao, X; Cafaro, J; McLaughlin, AJ; Postma, FR; Paul, DL; Awatramani, G; Field, GD

Published Date

  • October 10, 2018

Published In

Volume / Issue

  • 100 / 1

Start / End Page

  • 216 - 228.e6

PubMed ID

  • 30220512

Pubmed Central ID

  • 30220512

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2018.08.021

Language

  • eng

Conference Location

  • United States