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Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice.

Publication ,  Journal Article
Garner, AM; Norton, JN; Kinard, WL; Kissling, GE; Reynolds, RP
Published in: J Am Assoc Lab Anim Sci
September 1, 2018

Despite documented adverse effects, limits for rodent exposure to vibration in the laboratory animal facility have not been established. This study used female C57BL/6 mice to determine the frequencies of vibration at which mice were most sensitive to behavioral changes, the highest magnitude of vibration that would not cause behavioral changes, the behavioral changes that occur in response to vibration, and the extent to which mice habituate to vibration. Mice were exposed to frequencies of vibration between 20 and 190 Hz at accelerations of 0.05 to 1.0 m/s2. Behavioral responses were videorecorded and subsequently scored. Mice showed the most behavioral responses at 1.0 m/s2. At intermediate accelerations of 0.5 and 0.75 m/s2, behavioral responses were most prevalent at frequencies of 70 to 100 Hz. In contrast, at an acceleration of 0.05 m/s2, mice did not show any discernible behavioral response. Behavioral responses induced by the initiation of vibration were transient, generally lasting only 2 to 10 s. Behaviors in awake mice included abrupt freezing of motion, hunched posture, and surveying the cage environment. In mice that were asleep, responses consisted of lifting the head suddenly with or without prior shifting of body position. When exposed to multiple periods of vibration over a short time, responses seemed to decrease. In summary, mice were particularly sensitive to vibration between 70 to 100 Hz, did not respond to the slowest acceleration (0.05 m/s2), and exhibited transient responses at the initiation of vibration.

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Published In

J Am Assoc Lab Anim Sci

DOI

EISSN

2769-6677

Publication Date

September 1, 2018

Volume

57

Issue

5

Start / End Page

447 / 455

Location

United States

Related Subject Headings

  • Vibration
  • Veterinary Sciences
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Female
  • Behavior, Animal
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Garner, A. M., Norton, J. N., Kinard, W. L., Kissling, G. E., & Reynolds, R. P. (2018). Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice. J Am Assoc Lab Anim Sci, 57(5), 447–455. https://doi.org/10.30802/AALAS-JAALAS-17-00092
Garner, Angela M., John N. Norton, Will L. Kinard, Grace E. Kissling, and Randall P. Reynolds. “Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice.J Am Assoc Lab Anim Sci 57, no. 5 (September 1, 2018): 447–55. https://doi.org/10.30802/AALAS-JAALAS-17-00092.
Garner AM, Norton JN, Kinard WL, Kissling GE, Reynolds RP. Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice. J Am Assoc Lab Anim Sci. 2018 Sep 1;57(5):447–55.
Garner, Angela M., et al. “Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice.J Am Assoc Lab Anim Sci, vol. 57, no. 5, Sept. 2018, pp. 447–55. Pubmed, doi:10.30802/AALAS-JAALAS-17-00092.
Garner AM, Norton JN, Kinard WL, Kissling GE, Reynolds RP. Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice. J Am Assoc Lab Anim Sci. 2018 Sep 1;57(5):447–455.

Published In

J Am Assoc Lab Anim Sci

DOI

EISSN

2769-6677

Publication Date

September 1, 2018

Volume

57

Issue

5

Start / End Page

447 / 455

Location

United States

Related Subject Headings

  • Vibration
  • Veterinary Sciences
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Female
  • Behavior, Animal
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences