Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice.

Published

Journal Article

Despite documented adverse effects, limits for rodent exposure to vibration in the laboratory animal facility have not been established. This study used female C57BL/6 mice to determine the frequencies of vibration at which mice were most sensitive to behavioral changes, the highest magnitude of vibration that would not cause behavioral changes, the behavioral changes that occur in response to vibration, and the extent to which mice habituate to vibration. Mice were exposed to frequencies of vibration between 20 and 190 Hz at accelerations of 0.05 to 1.0 m/s2. Behavioral responses were videorecorded and subsequently scored. Mice showed the most behavioral responses at 1.0 m/s2. At intermediate accelerations of 0.5 and 0.75 m/s2, behavioral responses were most prevalent at frequencies of 70 to 100 Hz. In contrast, at an acceleration of 0.05 m/s2, mice did not show any discernible behavioral response. Behavioral responses induced by the initiation of vibration were transient, generally lasting only 2 to 10 s. Behaviors in awake mice included abrupt freezing of motion, hunched posture, and surveying the cage environment. In mice that were asleep, responses consisted of lifting the head suddenly with or without prior shifting of body position. When exposed to multiple periods of vibration over a short time, responses seemed to decrease. In summary, mice were particularly sensitive to vibration between 70 to 100 Hz, did not respond to the slowest acceleration (0.05 m/s2), and exhibited transient responses at the initiation of vibration.

Full Text

Duke Authors

Cited Authors

  • Garner, AM; Norton, JN; Kinard, WL; Kissling, GE; Reynolds, RP

Published Date

  • September 1, 2018

Published In

Volume / Issue

  • 57 / 5

Start / End Page

  • 447 - 455

PubMed ID

  • 30060780

Pubmed Central ID

  • 30060780

International Standard Serial Number (ISSN)

  • 1559-6109

Digital Object Identifier (DOI)

  • 10.30802/AALAS-JAALAS-17-00092

Language

  • eng

Conference Location

  • United States