Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Nephrotic syndrome (NS) results in hypercoagulability and increased risk of infection. Furthermore, infection increases the risk of venous thromboembolism (VTE). Our objective was to determine the prevalence of infection, VTE, and the associated outcomes among a cohort of hospitalized children with NS. METHODS: All children with NS admitted to 17 pediatric hospitals across North America from 2010 to 2012 were included. Prevalence of infection and VTE was determined. Wilcoxon rank-sum and logistic regression were performed. RESULTS: Seven-hundred thirty hospitalizations occurred among 370 children with NS. One-hundred forty-eight children (40%) had ≥ 1 infection (211 episodes) and 11 (3%) had VTE. Those with VTE had infection more frequently (p = 0.046) and were younger at NS diagnosis (3.0 vs. 4.0 years; p = 0.008). The most common infectious pathogen identified was Streptococcus pneumoniae. The median hospital length of stay for those with infection [10 vs 5 days (p < 0.0001)] or VTE [22 vs 6 days (p < 0.0001)] was longer than those without either complication. Of those with infection, 13% had an intensive care unit (ICU) stay compared with 3.3% of those without infection. Median ICU stay was 4 days in those with VTE compared to 0 days in those without (p < 0.001). By logistic regression, only the number of ICU days was associated with VTE (OR 1.074, 95% CI 1.013-1.138). CONCLUSIONS: Hospitalized children with NS have high rates of infection. Presence of VTE was associated with infection. Both were associated with longer hospitalizations and ICU stays.

Full Text

Duke Authors

Cited Authors

  • Carpenter, SL; Goldman, J; Sherman, AK; Selewski, DT; Kallash, M; Tran, CL; Seamon, M; Katsoufis, C; Ashoor, I; Hernandez, J; Supe-Markovina, K; D'alessandri-Silva, C; DeJesus-Gonzalez, N; Vasylyeva, TL; Formeck, C; Woll, C; Gbadegesin, R; Geier, P; Devarajan, P; Smoyer, WE; Kerlin, BA; Rheault, MN

Published Date

  • February 2019

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 261 - 267

PubMed ID

  • 30194664

Pubmed Central ID

  • PMC6628263

Electronic International Standard Serial Number (EISSN)

  • 1432-198X

Digital Object Identifier (DOI)

  • 10.1007/s00467-018-4072-6


  • eng

Conference Location

  • Germany