Antithrombotic Strategies and Device Thrombosis.


Journal Article (Review)

Despite improvements in left ventricular assist device (LVAD) technology, bleeding and thrombotic complications are major concerns that adversely influence morbidity and mortality. Current antithrombotic therapy recommendations for LVAD thrombosis prophylaxis are largely derived from clinical device trials that implement a one-size-fits-all strategy. Objective serial laboratory-based assessment of thrombogenicity is needed to balance the risk of bleeding and thrombotic complications. Finally, the newest-generation device, the HeartMate 3, has been associated with lower levels of shear and reduced hemolysis that may mitigate thrombotic event occurrences.

Full Text

Duke Authors

Cited Authors

  • Gurbel, PA; Shah, P; Desai, S; Tantry, US

Published Date

  • November 2018

Published In

Volume / Issue

  • 36 / 4

Start / End Page

  • 541 - 550

PubMed ID

  • 30297071

Pubmed Central ID

  • 30297071

Electronic International Standard Serial Number (EISSN)

  • 1558-2264

Digital Object Identifier (DOI)

  • 10.1016/j.ccl.2018.06.008


  • eng

Conference Location

  • Netherlands