Interferon-gamma for delayed pulmonary toxicity syndrome resistant to steroids.


Journal Article

Delayed pulmonary toxicity syndrome, characterized by interstitial pneumonia and pulmonary fibrosis, is common following high-dose bischloroethylnitrosourea (BCNU) (carmustine, [1,3-bis (2-chloroethyl)-1-nitrosourea]) containing chemotherapeutic regimens. Depending upon the treatment protocol, it may develop in over 70% of patients. Early and aggressive corticosteroid treatment leads to improvement in the majority of patients. However, up to 8% of affected patients may fail to respond to corticosteroids and develop progressive respiratory failure leading to death. No alternatives to corticosteroids have thus far been shown useful. We report the symptomatic and physiological improvement of a patient with severe steroid-resistant delayed pulmonary toxicity syndrome, following treatment with interferon-gamma.

Full Text

Duke Authors

Cited Authors

  • Suratt, BT; Lynch, DA; Cool, CD; Jones, RB; Brown, KK

Published Date

  • May 2003

Published In

Volume / Issue

  • 31 / 10

Start / End Page

  • 939 - 941

PubMed ID

  • 12748674

Pubmed Central ID

  • 12748674

International Standard Serial Number (ISSN)

  • 0268-3369

Digital Object Identifier (DOI)

  • 10.1038/sj.bmt.1704032


  • eng

Conference Location

  • England