Use of amifostine in bone marrow purging.


Conference Paper

One of the main obstacles for the use of high-dose chemotherapy with autologous hematopoietic progenitor cell support in the treatment of malignancies is the possibility of reinfusing clonogenic tumor cells with the hematopoietic graft. Purging of the graft with chemicals can reduce the number of tumor cells but can also damage the normal hematopoietic progenitors. Preclinical studies showed that the phosphorylated sulfhydryl compound amifostine (WR-2721) can protect normal hematopoietic progenitors from damage from alkylating agents. We conducted a randomized clinical trial in patients with breast cancer, non-Hodgkin's lymphoma, and Hodgkin's disease undergoing autologous bone marrow transplant. In this study, patients were randomized to have their bone marrow purged with 4-hydroperoxycyclophosphamide (4-HC) with (arm A) or without (arm B) amifostine. The percentage of colony-forming unit granulocyte-macrophages recovered after purging was higher in the amifostine arm, both in patients with breast cancer and in those with lymphoma, although this difference was not statistically significant. In addition, the time to engraftment was significantly shorter in the amifostine arm in both cohorts. We showed that pretreatment of bone marrow with amifostine prior to purging with 4-HC can protect normal hematopoietic progenitors from damage by 4-HC. This resulted in shorter engraftment rates and less need for supportive care.

Full Text

Duke Authors

Cited Authors

  • Cagnoni, PJ; Jones, RB; Bearman, SI; Ross, M; Hami, L; Franklin, WA; Capizzi, R; Schein, PS; Shpall, EJ

Published Date

  • August 1996

Published In

Volume / Issue

  • 23 / 4 Suppl 8

Start / End Page

  • 44 - 48

PubMed ID

  • 8783666

Pubmed Central ID

  • 8783666

International Standard Serial Number (ISSN)

  • 0093-7754

Conference Location

  • United States