Pathogenesis of varicose veins.

Journal Article (Journal Article;Review)

Despite the high prevalence of varicose veins and the recent surge in research on the condition, the precise mechanisms underlying their development remain uncertain. In the past decade, there has been a shift from initial theories based on purely mechanical factors to hypotheses pointing to complex molecular changes causing histologic alterations in the vessel wall and extracellular matrix. Despite progress in understanding the molecular aspects of venous insufficiency, therapies for symptomatic varicose veins are directed toward anatomic and physical interventions. The present report reviews current evidence identifying the underlying biochemical alterations in the pathogenesis of varicose veins.

Full Text

Duke Authors

Cited Authors

  • Oklu, R; Habito, R; Mayr, M; Deipolyi, AR; Albadawi, H; Hesketh, R; Walker, TG; Linskey, KR; Long, CA; Wicky, S; Stoughton, J; Watkins, MT

Published Date

  • January 2012

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 33 - 39

PubMed ID

  • 22030459

Electronic International Standard Serial Number (EISSN)

  • 1535-7732

Digital Object Identifier (DOI)

  • 10.1016/j.jvir.2011.09.010


  • eng

Conference Location

  • United States