Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor.

Published

Journal Article

SQBAzide, a biotinylated, azido derivative of the TXA2 receptor antagonist, SQ31,491, was synthesized and characterized. The compound specifically inhibited human platelet aggregation mediated by TXA2 receptor activation and irreversibly labeled platelet TXA2 receptors upon exposure to ultraviolet light. This probe should prove to be of significant value for the study of the receptor-ligand binding domain.

Full Text

Duke Authors

Cited Authors

  • Halmos, T; Turek, JW; Le Breton, GC; Antonakis, K

Published Date

  • October 1999

Published In

Volume / Issue

  • 9 / 20

Start / End Page

  • 2963 - 2968

PubMed ID

  • 10571156

Pubmed Central ID

  • 10571156

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(99)00511-9

Language

  • eng