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Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis.

Publication ,  Journal Article
Zwischenberger, BA; Beasley, MM; Davenport, DL; Xenos, ES
Published in: Vasc Endovascular Surg
November 2013

PURPOSE: To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS). MATERIALS AND METHODS: A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls. RESULTS: In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I (2) = 18, P = .279). CONCLUSIONS: The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS.

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Published In

Vasc Endovascular Surg

DOI

EISSN

1938-9116

Publication Date

November 2013

Volume

47

Issue

8

Start / End Page

620 / 624

Location

United States

Related Subject Headings

  • Venous Insufficiency
  • Ultrasonography, Doppler, Color
  • Spinal Cord
  • Risk Factors
  • Risk Assessment
  • Prevalence
  • Predictive Value of Tests
  • Odds Ratio
  • Multiple Sclerosis
  • Humans
 

Citation

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Zwischenberger, B. A., Beasley, M. M., Davenport, D. L., & Xenos, E. S. (2013). Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis. Vasc Endovascular Surg, 47(8), 620–624. https://doi.org/10.1177/1538574413503562
Zwischenberger, Brittany A., Mary M. Beasley, Daniel L. Davenport, and Eleftherios S. Xenos. “Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis.Vasc Endovascular Surg 47, no. 8 (November 2013): 620–24. https://doi.org/10.1177/1538574413503562.
Zwischenberger BA, Beasley MM, Davenport DL, Xenos ES. Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis. Vasc Endovascular Surg. 2013 Nov;47(8):620–4.
Zwischenberger, Brittany A., et al. “Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis.Vasc Endovascular Surg, vol. 47, no. 8, Nov. 2013, pp. 620–24. Pubmed, doi:10.1177/1538574413503562.
Zwischenberger BA, Beasley MM, Davenport DL, Xenos ES. Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis. Vasc Endovascular Surg. 2013 Nov;47(8):620–624.
Journal cover image

Published In

Vasc Endovascular Surg

DOI

EISSN

1938-9116

Publication Date

November 2013

Volume

47

Issue

8

Start / End Page

620 / 624

Location

United States

Related Subject Headings

  • Venous Insufficiency
  • Ultrasonography, Doppler, Color
  • Spinal Cord
  • Risk Factors
  • Risk Assessment
  • Prevalence
  • Predictive Value of Tests
  • Odds Ratio
  • Multiple Sclerosis
  • Humans