Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases.

Published

Journal Article

BACKGROUND: This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. METHODS: A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score. The score was compared with the current standard (Fong score) and validated in an external cohort of patients from the Memorial Sloan Kettering Cancer Center (MSKCC). RESULTS: Six preoperative predictors of worse OS were identified on multivariable Cox regression analysis in the JHH cohort (502 patients). The GAME score was calculated by allocating points to each patient according to the presence of these predictive factors: KRAS-mutated tumours (1 point); carcinoembryonic antigen level 20 ng/ml or more (1 point), primary tumour lymph node metastasis (1 point); Tumour Burden Score between 3 and 8 (1 point) or 9 and over (2 points); and extrahepatic disease (2 points). The high-risk group in the JHH cohort (GAME score at least 4 points) had a 5-year OS rate of 11 per cent, compared with 73·4 per cent for those in the low-risk group (score 0-1 point). Importantly, in cohorts from both the JHH and MSKCC (747 patients), the discriminatory capacity of the GAME score was superior to that of the Fong score, as demonstrated by the C-index and the Akaike information criterion. CONCLUSION: The GAME score is a preoperative prognostic tool that can be used to inform treatment selection.

Full Text

Duke Authors

Cited Authors

  • Margonis, GA; Sasaki, K; Gholami, S; Kim, Y; Andreatos, N; Rezaee, N; Deshwar, A; Buettner, S; Allen, PJ; Kingham, TP; Pawlik, TM; He, J; Cameron, JL; Jarnagin, WR; Wolfgang, CL; D'Angelica, MI; Weiss, MJ

Published Date

  • August 2018

Published In

Volume / Issue

  • 105 / 9

Start / End Page

  • 1210 - 1220

PubMed ID

  • 29691844

Pubmed Central ID

  • 29691844

Electronic International Standard Serial Number (EISSN)

  • 1365-2168

Digital Object Identifier (DOI)

  • 10.1002/bjs.10838

Language

  • eng

Conference Location

  • England