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Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer.

Publication ,  Journal Article
Simpson, AL; Doussot, A; Creasy, JM; Adams, LB; Allen, PJ; DeMatteo, RP; Gönen, M; Kemeny, NE; Kingham, TP; Shia, J; Jarnagin, WR; Do, RKG ...
Published in: Ann Surg Oncol
September 2017

BACKGROUND: Recurrence after resection of colorectal liver metastases (CRLMs) occurs in up to 75% of patients. Preoperative prediction of hepatic recurrence may inform therapeutic strategies at the time of initial resection. Texture analysis (TA) is an established technique that quantifies pixel intensity variations (heterogeneity) on cross-sectional imaging. We hypothesized that tumoral and parenchymal changes that are predictive of overall survival (OS) and recurrence in the future liver remnant (FLR) can be detected using TA on preoperative computed tomography (CT) images. METHODS: Patients who underwent resection for CRLM between 2003 and 2007 with appropriate preoperative CT scans were included (n = 198) in this retrospective study. Texture features extracted from the tumor and FLR, and clinicopathologic variables, were incorporated into a multivariable survival model. RESULTS: Quantitative imaging features of the FLR were an independent predictor of both OS and hepatic disease-free survival (HDFS). Tumor texture showed significant association with OS. TA of the FLR allowed patient stratification into two groups, with significantly different risks of hepatic recurrence (hazard ratio 2.09, 95% confidence interval 1.33-3.28; p = 0.001). Patients with homogeneous parenchyma had approximately twice the risk of hepatic recurrence (41 vs. 20%). CONCLUSION: TA of the tumor and FLR are independently associated with OS, and TA of the FLR is independently associated with HDFS. Patients with homogeneous parenchyma had a significantly higher risk of hepatic recurrence. Preoperative TA of the liver represents a potential biomarker to identify patients at risk of liver recurrence after resection for CRLM.

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Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

September 2017

Volume

24

Issue

9

Start / End Page

2482 / 2490

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Survival Rate
  • Retrospective Studies
  • Preoperative Period
  • Parenchymal Tissue
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Liver Neoplasms
 

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Simpson, A. L., Doussot, A., Creasy, J. M., Adams, L. B., Allen, P. J., DeMatteo, R. P., … D’Angelica, M. I. (2017). Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer. Ann Surg Oncol, 24(9), 2482–2490. https://doi.org/10.1245/s10434-017-5896-1
Simpson, Amber L., Alexandre Doussot, John M. Creasy, Lauryn B. Adams, Peter J. Allen, Ronald P. DeMatteo, Mithat Gönen, et al. “Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer.Ann Surg Oncol 24, no. 9 (September 2017): 2482–90. https://doi.org/10.1245/s10434-017-5896-1.
Simpson AL, Doussot A, Creasy JM, Adams LB, Allen PJ, DeMatteo RP, et al. Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer. Ann Surg Oncol. 2017 Sep;24(9):2482–90.
Simpson, Amber L., et al. “Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer.Ann Surg Oncol, vol. 24, no. 9, Sept. 2017, pp. 2482–90. Pubmed, doi:10.1245/s10434-017-5896-1.
Simpson AL, Doussot A, Creasy JM, Adams LB, Allen PJ, DeMatteo RP, Gönen M, Kemeny NE, Kingham TP, Shia J, Jarnagin WR, Do RKG, D’Angelica MI. Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer. Ann Surg Oncol. 2017 Sep;24(9):2482–2490.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

September 2017

Volume

24

Issue

9

Start / End Page

2482 / 2490

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Survival Rate
  • Retrospective Studies
  • Preoperative Period
  • Parenchymal Tissue
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Liver Neoplasms