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Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease.

Publication ,  Conference
Sadot, E; Basturk, O; Klimstra, DS; Gönen, M; Lokshin, A; Do, RKG; D'Angelica, MI; DeMatteo, RP; Kingham, TP; Jarnagin, WR; Allen, PJ
Published in: Ann Surg
December 2015

OBJECTIVES: To evaluate the association of tumor-associated neutrophils (TANs) with malignant progression in intraductal papillary mucinous neoplasms (IPMNs) and to study the cyst fluid from these lesions for biomarkers of the inflammation-carcinogenesis association. BACKGROUND: There is a strong link between TANs and malignant progression. Inflammatory mediators released by these cells may be a measurable surrogate marker of this progression. METHODS: We evaluated 78 resected IPMNs (2004-2013). Lesions were divided into the low-risk (low- and intermediate-grade dysplasia: n = 48) and high-risk (high-grade dysplasia and invasive carcinoma: n = 30) groups. TANs were assessed and categorized (negative, low, and high). A multiplexed assay was performed to evaluate 87 different cyst fluid proteins, including cyst fluid inflammatory markers (CFIMs), as possible surrogate markers for parenchymal inflammation. RESULTS: Significant positive correlation between grade of dysplasia and TANs was found. High levels of TANs were identified in 2%, 33%, and 89% of the lesions when stratified by grade of dysplasia into low/intermediate-grade dysplasia, high-grade dysplasia, and invasive carcinoma, respectively (P < 0.001). Higher grades of dysplasia were also found to have positive correlation with 29 of the measured proteins, of which 23 (79%) were CFIMs. Higher levels of TANs correlated with higher levels of 18 CFIMs, of which 16 (89%) were also found to be associated with higher grades of dysplasia. CONCLUSIONS: In this study, TANs were strongly associated with malignant progression in IPMNs. Measurement of CFIMs may be a surrogate marker for IPMN progression and allow for the identification of high-risk disease.

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Published In

Ann Surg

DOI

EISSN

1528-1140

Publication Date

December 2015

Volume

262

Issue

6

Start / End Page

1102 / 1107

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Pancreatic Neoplasms
  • Neutrophils
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
  • Disease Progression
 

Citation

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MLA
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Sadot, E., Basturk, O., Klimstra, D. S., Gönen, M., Lokshin, A., Do, R. K. G., … Allen, P. J. (2015). Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease. In Ann Surg (Vol. 262, pp. 1102–1107). United States. https://doi.org/10.1097/SLA.0000000000001044
Sadot, Eran, Olca Basturk, David S. Klimstra, Mithat Gönen, Anna Lokshin, Richard Kinh Gian Do, Michael I. D’Angelica, et al. “Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease.” In Ann Surg, 262:1102–7, 2015. https://doi.org/10.1097/SLA.0000000000001044.
Sadot, Eran, et al. “Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease.Ann Surg, vol. 262, no. 6, 2015, pp. 1102–07. Pubmed, doi:10.1097/SLA.0000000000001044.
Sadot E, Basturk O, Klimstra DS, Gönen M, Lokshin A, Do RKG, D’Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Allen PJ. Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease. Ann Surg. 2015. p. 1102–1107.

Published In

Ann Surg

DOI

EISSN

1528-1140

Publication Date

December 2015

Volume

262

Issue

6

Start / End Page

1102 / 1107

Location

United States

Related Subject Headings

  • Surgery
  • Retrospective Studies
  • Pancreatic Neoplasms
  • Neutrophils
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Female
  • Disease Progression