Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors.


Journal Article

Duodenal neuroendocrine tumors are rare and few studies exist to guide surgical management. This study identifies factors associated with recurrence after resection.A retrospective, single institution review was performed between 1983 and 2011 on patients with a pathologic diagnosis of duodenal neuroendocrine tumor. Tumor grade was assigned based on WHO 2010 criteria (Ki-67 and mitotic rate).Seventy-five patients were identified that underwent curative resection. This included 12 patients with endoscopic mucosal resection, 34 that had local resection, and 29 that underwent pancreaticoduodenectomy. Two-year and 5-year recurrence-free survival was 84 and 81%, respectively. There were 11 tumor recurrences (either local or distant), and four patients died of their disease (3/4 had high-grade lesions) with an overall median follow-up of 27 months. On univariate analysis, tumor size and tumor grade were identified as being associated with recurrence, but not intervention type, lymph node metastases, ampullary location, or margin status.Tumor grade and size are associated with recurrence-free survival in duodenal neuroendocrine tumors. When feasible, a less aggressive surgical approach to treat low-grade and low-stage duodenal NETs should be considered.

Full Text

Duke Authors

Cited Authors

  • Untch, BR; Bonner, KP; Roggin, KK; Reidy-Lagunes, D; Klimstra, DS; Schattner, MA; Fong, Y; Allen, PJ; D'Angelica, MI; DeMatteo, RP; Jarnagin, WR; Kingham, TP; Tang, LH

Published Date

  • March 2014

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 457 - 462

PubMed ID

  • 24448999

Pubmed Central ID

  • 24448999

Electronic International Standard Serial Number (EISSN)

  • 1873-4626

International Standard Serial Number (ISSN)

  • 1091-255X

Digital Object Identifier (DOI)

  • 10.1007/s11605-014-2456-x


  • eng