Patterns of recurrence after ablation of colorectal cancer liver metastases.

Journal Article (Journal Article)

PURPOSE: To determine the local recurrence rate and factors associated with recurrence after intraoperative ablation of colorectal cancer liver metastases. METHODS: A retrospective analysis of a prospectively maintained database was performed for patients who underwent ablation of a hepatic colorectal cancer metastasis in the operating room from April 1996 to March 2010. Kaplan-Meier survival curves and Cox models were used to determine recurrence rates and assess significance. RESULTS: Ablation was performed in 10% (n = 158 patients) of all cases during the study period. Seventy-eight percent were performed in conjunction with a liver resection. Of the 315 tumors ablated, most tumors were ≤ 1 cm in maximum diameter (53%). Radiofrequency ablation was used to treat most of the tumors (70%). Thirty-six tumors (11%) had local recurrence as part of their recurrence pattern. Disease recurred in the liver or systemically after 212 tumors (67%) were ablated. On univariate analysis, tumor size greater than 1 cm was associated with a significantly increased risk of local recurrence (hazard ratio 2.3, 95% confidence interval 1.2-4.5, P = 0.013). The 2 year ablation zone recurrence-free survival was 92% for tumors ≤ 1 cm compared to 81% for tumors >1 cm. On multivariate analysis, tumor size of >1 cm, lack of postoperative chemotherapy, and use of cryotherapy were significantly associated with a higher local recurrence rate. CONCLUSIONS: Intraoperative ablation appears to be highly effective treatment for hepatic colorectal tumors ≤ 1 cm.

Full Text

Duke Authors

Cited Authors

  • Kingham, TP; Tanoue, M; Eaton, A; Rocha, FG; Do, R; Allen, P; De Matteo, RP; D'Angelica, M; Fong, Y; Jarnagin, WR

Published Date

  • March 2012

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 834 - 841

PubMed ID

  • 21879262

Electronic International Standard Serial Number (EISSN)

  • 1534-4681

Digital Object Identifier (DOI)

  • 10.1245/s10434-011-2048-x


  • eng

Conference Location

  • United States