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Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma.

Publication ,  Journal Article
Allen, PJ; Busam, K; Hill, AD; Stojadinovic, A; Coit, DG
Published in: Cancer
September 15, 2001

BACKGROUND: Immunohistochemical analysis of sentinel lymph nodes from patients with breast carcinoma and melanoma has been shown to increase the sensitivity for detecting lymph node metastases. To the authors' knowledge, this technique has not been described in patients with Merkel cell carcinoma. METHODS: Lymphatic mapping and sentinel lymph node biopsy was performed on 26 patients with Merkel cell carcinoma between 1997 and 1999. All sentinel lymph nodes were analyzed with conventional hematoxylin and eosin (H&E) staining and then analyzed with immunohistochemical staining to evaluate whether this additional technique would increase the number of patients found to have lymph node metastasis. RESULTS: The median age of the patients in the current study was 67 years and the median tumor size at the time of presentation was 2 cm. Lymph node metastases were identified in 5 of the 26 patients (19%). Three of these five lymph node positive patients were identified with H&E staining. The remaining two patients were identified only after immunohistochemical analysis. The median follow-up in this group of lymph node positive patients was 14 months, with 2 of the 5 lymph node positive patients developing a recurrence. The median follow-up in the 21 patients who were lymph node negative was 19 months, with only 1 patient having developed a recurrence at the time of last follow-up. CONCLUSIONS: Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma appears to increase the sensitivity of detecting clinically occult lymph node metastases.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 15, 2001

Volume

92

Issue

6

Start / End Page

1650 / 1655

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Lymph Nodes
  • Immunohistochemistry
  • Humans
  • Follow-Up Studies
 

Citation

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Allen, P. J., Busam, K., Hill, A. D., Stojadinovic, A., & Coit, D. G. (2001). Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma. Cancer, 92(6), 1650–1655. https://doi.org/10.1002/1097-0142(20010915)92:6<1650::aid-cncr1491>3.0.co;2-8
Allen, P. J., K. Busam, A. D. Hill, A. Stojadinovic, and D. G. Coit. “Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma.Cancer 92, no. 6 (September 15, 2001): 1650–55. https://doi.org/10.1002/1097-0142(20010915)92:6<1650::aid-cncr1491>3.0.co;2-8.
Allen PJ, Busam K, Hill AD, Stojadinovic A, Coit DG. Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma. Cancer. 2001 Sep 15;92(6):1650–5.
Allen, P. J., et al. “Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma.Cancer, vol. 92, no. 6, Sept. 2001, pp. 1650–55. Pubmed, doi:10.1002/1097-0142(20010915)92:6<1650::aid-cncr1491>3.0.co;2-8.
Allen PJ, Busam K, Hill AD, Stojadinovic A, Coit DG. Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma. Cancer. 2001 Sep 15;92(6):1650–1655.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 15, 2001

Volume

92

Issue

6

Start / End Page

1650 / 1655

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Lymph Nodes
  • Immunohistochemistry
  • Humans
  • Follow-Up Studies