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The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma.

Publication ,  Journal Article
Ferrone, CR; Haas, B; Tang, L; Coit, DG; Fong, Y; Brennan, MF; Allen, PJ
Published in: J Gastrointest Surg
December 2006

The American Joint Committee on Cancer (AJCC) staging system for pancreatic adenocarcinoma classifies positive peritoneal cytology as stage IV disease. Data are limited with respect to the prevalence of positive peritoneal cytology and its influence on survival in patients with resectable, locally advanced, and metastatic disease. Four hundred sixty-two patients underwent staging laparoscopy for pancreatic adenocarcinoma between January 1995 and December 2005. Kaplan-Meier survival comparisons were performed to evaluate the significance of positive peritoneal cytology on overall survival (OS) in resected patients and patients with locally advanced and metastatic disease. Of the 462 patients, 47% (217/462) underwent a pancreatic resection. The 21% (95/462) with locally advanced disease and 32% (150/462) with metastatic disease did not undergo resection. Peritoneal cytology was positive in 17% (77/462), and was associated with stage of disease (metastatic, 37%; locally advanced, 11%; resected, 5%; P=0.01). Positive cytology was not associated with OS in patients with metastatic disease or locally advanced disease, but was in resected patients (median, 16 months vs. 8 months; P<0.001). Node-positive disease was present in 8 of 10 patients resected with positive cytology (2 years OS, 12% positive cytology vs. 23% negative; P=0.006). In this study, patients who underwent resection in the presence of positive peritoneal cytology and absence of other identifiable metastatic disease had a similar survival as other patients with stage IV disease.

Duke Scholars

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

December 2006

Volume

10

Issue

10

Start / End Page

1347 / 1353

Location

Netherlands

Related Subject Headings

  • Survival Analysis
  • Surgery
  • Peritoneum
  • Peritoneal Neoplasms
  • Pancreatic Neoplasms
  • Nomograms
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Laparoscopy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ferrone, C. R., Haas, B., Tang, L., Coit, D. G., Fong, Y., Brennan, M. F., & Allen, P. J. (2006). The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma. J Gastrointest Surg, 10(10), 1347–1353. https://doi.org/10.1016/j.gassur.2006.07.013
Ferrone, Cristina R., Barbara Haas, Laura Tang, Daniel G. Coit, Yuman Fong, Murray F. Brennan, and Peter J. Allen. “The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma.J Gastrointest Surg 10, no. 10 (December 2006): 1347–53. https://doi.org/10.1016/j.gassur.2006.07.013.
Ferrone CR, Haas B, Tang L, Coit DG, Fong Y, Brennan MF, et al. The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma. J Gastrointest Surg. 2006 Dec;10(10):1347–53.
Ferrone, Cristina R., et al. “The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma.J Gastrointest Surg, vol. 10, no. 10, Dec. 2006, pp. 1347–53. Pubmed, doi:10.1016/j.gassur.2006.07.013.
Ferrone CR, Haas B, Tang L, Coit DG, Fong Y, Brennan MF, Allen PJ. The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma. J Gastrointest Surg. 2006 Dec;10(10):1347–1353.
Journal cover image

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

December 2006

Volume

10

Issue

10

Start / End Page

1347 / 1353

Location

Netherlands

Related Subject Headings

  • Survival Analysis
  • Surgery
  • Peritoneum
  • Peritoneal Neoplasms
  • Pancreatic Neoplasms
  • Nomograms
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Laparoscopy