Use of intraoperative ablation as an adjunct to surgical resection in the treatment of recurrent colorectal liver metastases.

Published

Journal Article

OBJECTIVE: To evaluate the role of intraoperative ablation as an adjunct to resection in patients with recurrent colorectal liver metastases (rCLM). METHODS: All patients undergoing curative-intent reoperative surgery for rCLM from 1992 to 2009 at a tertiary cancer center were included. Overall survival (OS) and recurrence-free survival (RFS) were compared between patients treated with resection alone or in combination with ablation. RESULTS: A total of 112 reoperative hepatectomies were performed, of which 16 were combined with ablation. The proportion of patients treated with resection and ablation increased from 0% to 41%. Patients undergoing resection and ablation had a greater tumor burden (median, 4 vs. 1, p < 0.0001) and higher baseline clinical risk scores (median, 3 vs. 2, p = 0.065) than patients undergoing resection alone. Patients undergoing resection and ablation had lower intraoperative blood loss than patients undergoing resection alone (344 vs. 877 ml, p = 0.018). Five-year OS from the time of surgery was 48.6%. In multivariable analysis, there was no significant difference in OS or RFS based on the treatment modality. CONCLUSION: In patients with rCLM, the use of intraoperative ablation can extend the limits of surgical resection in patients with disease that might otherwise not be amenable to complete resection.

Full Text

Duke Authors

Cited Authors

  • Govindarajan, A; Arnaoutakis, D; D'Angelica, M; Allen, PJ; DeMatteo, RP; Blumgart, LH; Jarnagin, WR; Fong, Y

Published Date

  • July 2011

Published In

Volume / Issue

  • 15 / 7

Start / End Page

  • 1168 - 1172

PubMed ID

  • 21557021

Pubmed Central ID

  • 21557021

Electronic International Standard Serial Number (EISSN)

  • 1873-4626

Digital Object Identifier (DOI)

  • 10.1007/s11605-011-1470-5

Language

  • eng

Conference Location

  • United States