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Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center.

Publication ,  Journal Article
Butte, JM; Do, RK; Shia, J; Gönen, M; D'Angelica, MI; Getrajdman, GI; Allen, PJ; Fong, Y; Dematteo, RP; Klimstra, DS; Jarnagin, WR
Published in: Surgery
September 2011

BACKGROUND: Liver angiomyolipomas (AML) are mesenchymal neoplasms with an uncertain clinical behavior. The spectrum of presentation, imaging and histologic features, and outcomes were analyzed in all patients treated at Memorial Sloan-Kettering Cancer Center. METHODS: Demographics, disease, pathologic, treatment, and outcome-related variables for consecutive patients were reviewed retrospectively. All imaging studies obtained at presentation were reexamined, categorized, and compared using Fisher and Wilcoxon tests. RESULTS: Between 1989 and 2010, 238 patients with AML were seen and 22 (9.3%) had liver involvement (exclusive = 17; combined with kidney = 5). The median age was 53 years; 18 were females, and 15 had symptoms. AML was not suspected at initial presentation in any patient. Fat-containing neoplasms on imaging were larger (P = .03), with more heterogeneous enhancement compared with fat-poor neoplasms (P = .001), but none of the imaging/histologic features correlated with outcome. Thirteen patients underwent resection (R0 = 9), 4 were observed, 2 received chemotherapy, 2 embolization, and 1 embolization plus intra-arterial chemotherapy. Two patients treated with R0-resection recurred and 2 treated with chemotherapy progressed, but no patient died of AML-related causes. At a median follow-up of 36 months, 7 patients were free of disease, 13 were alive with disease, 1 died of an unrelated cause, and another was lost to follow-up. CONCLUSION: AMLs are rare neoplasms with an indolent course in most patients. Subtypes based on fat content are recognized, but clinical behavior does not seem to be different. Recurrence after resection is not associated with disease-related mortality. Resection may be unnecessary in selected asymptomatic patients if the diagnosis can be established definitively.

Duke Scholars

Published In

Surgery

DOI

EISSN

1532-7361

Publication Date

September 2011

Volume

150

Issue

3

Start / End Page

557 / 567

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Time Factors
  • Survival Analysis
  • Surgery
  • Statistics, Nonparametric
  • Retrospective Studies
  • Neoplasm Staging
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Butte, J. M., Do, R. K., Shia, J., Gönen, M., D’Angelica, M. I., Getrajdman, G. I., … Jarnagin, W. R. (2011). Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center. Surgery, 150(3), 557–567. https://doi.org/10.1016/j.surg.2011.03.006
Butte, Jean M., Richard K. Do, Jinru Shia, Mithat Gönen, Michael I. D’Angelica, George I. Getrajdman, Peter J. Allen, et al. “Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center.Surgery 150, no. 3 (September 2011): 557–67. https://doi.org/10.1016/j.surg.2011.03.006.
Butte JM, Do RK, Shia J, Gönen M, D’Angelica MI, Getrajdman GI, et al. Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center. Surgery. 2011 Sep;150(3):557–67.
Butte, Jean M., et al. “Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center.Surgery, vol. 150, no. 3, Sept. 2011, pp. 557–67. Pubmed, doi:10.1016/j.surg.2011.03.006.
Butte JM, Do RK, Shia J, Gönen M, D’Angelica MI, Getrajdman GI, Allen PJ, Fong Y, Dematteo RP, Klimstra DS, Jarnagin WR. Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center. Surgery. 2011 Sep;150(3):557–567.
Journal cover image

Published In

Surgery

DOI

EISSN

1532-7361

Publication Date

September 2011

Volume

150

Issue

3

Start / End Page

557 / 567

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Time Factors
  • Survival Analysis
  • Surgery
  • Statistics, Nonparametric
  • Retrospective Studies
  • Neoplasm Staging
  • Middle Aged
  • Male