A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.


Journal Article

Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.

Full Text

Cited Authors

  • Neumann, AM; Blondell, RD; Jaanimägi, U; Giambrone, AK; Homish, GG; Lozano, JR; Kowalik, U; Azadfard, M

Published Date

  • 2013

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 68 - 78

PubMed ID

  • 23480249

Pubmed Central ID

  • 23480249

Electronic International Standard Serial Number (EISSN)

  • 1545-0848

Digital Object Identifier (DOI)

  • 10.1080/10550887.2012.759872


  • eng

Conference Location

  • England