Combat Wound Initiative program.
The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.
Stojadinovic, A; Elster, E; Potter, BK; Davis, TA; Tadaki, DK; Brown, TS; Ahlers, S; Attinger, CE; Andersen, RC; Burris, D; Centeno, J; Champion, H; Crumbley, DR; Denobile, J; Duga, M; Dunne, JR; Eberhardt, J; Ennis, WJ; Forsberg, JA; Hawksworth, J; Helling, TS; Lazarus, GS; Milner, SM; Mullick, FG; Owner, CR; Pasquina, PF; Patel, CR; Peoples, GE; Nissan, A; Ring, M; Sandberg, GD; Schaden, W; Schultz, GS; Scofield, T; Shawen, SB; Sheppard, FR; Stannard, JP; Weina, PJ; Zenilman, JM
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