Alterations in renal function in psoriasis patients treated with cyclosporine, 5 mg/kg/day.


Journal Article

Cyclosporine has been used to treat a variety of cutaneous and immune-mediated diseases. Nephrotoxicity is the most common major adverse side effect.The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg/kg/day of cyclosporine.Sixteen patients with severe refractory psoriasis received cyclosporine, 5 mg/kg/day, for 12 weeks. Serum creatinine was evaluated with respect to each patient's baseline.Serum creatinine levels remained in the normal range, but 10 of 16 patients had a 30% elevation and 5 of 16 patients had a 50% elevation of serum creatinine compared with the patient's baseline value.These results indicate that a significant elevation in serum creatinine occurs in many patients who receive cyclosporine for psoriasis.

Full Text

Duke Authors

Cited Authors

  • Margolis, DJ; Guzzo, C; Johnson, J; Lazarus, GS

Published Date

  • February 1, 1992

Published In

Volume / Issue

  • 26 / 2 Pt 1

Start / End Page

  • 195 - 197

PubMed ID

  • 1552052

Pubmed Central ID

  • 1552052

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

International Standard Serial Number (ISSN)

  • 0190-9622


  • eng