Aggressive topical corticosteroid therapy: a novel approach to mast-cell-dependent cutaneous disorders.
Journal Article (Journal Article)
Topical corticosteroids are utilized in the treatment of a wide variety of skin diseases, primarily those involving an inflammatory component. Recent investigations have revealed that one of the effects of long-term usage of steroids is the depletion of skin mast cells. This led to the treatment of patients with urticaria pigmentosa with topical high potency corticosteroids for 6 weeks. At the end of treatment there was a marked reduction in tissue histamine and an absence of mast cells as well as a disappearance of pruritus and Darier's sign. Treated areas remained clinically improved for at least 9-12 months. Observations that corticosteroids profoundly affect mast cells in vivo provides a rationale to devise new treatment regimens for mast-cell-related diseases.
- Lavker, RM; Schechter, NM; Guzzo, C; Lazarus, GS
Volume / Issue
- 175 / 5
Start / End Page
- 213 - 216
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)