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Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report.

Publication ,  Journal Article
Rook, AH; Heald, PW; Nahass, GT; Macey, W; Witmer, WK; Lazarus, GS; Jegasothy, BV
Published in: Yale J Biol Med
1989

Extracorporeal photochemotherapy is a new form of immunotherapy which involves the extracorporeal photoinactivation of peripheral blood cells by 8-methoxypsoralen in the presence of ultraviolet A irradiation, followed by readministration of the cells. To explore the efficacy of this therapy in the treatment of autoimmune disease, four patients with a lengthy history of corticosteroid and immunosuppressive drug-resistant pemphigus vulgaris were initiated on extracorporeal photochemotherapy. Three patients experienced a complete remission in cutaneous disease expression, permitting discontinuation of medications in two and a substantial decrease in the third. Significant reductions in serum antiepidermal cell antibody titers occurred in all four patients. The treatments were well tolerated without the occurrence of adverse events. These results in a small number of patients suggest that extracorporeal photochemotherapy may prove to be a useful tool in the treatment of aggressive autoimmune disease.

Duke Scholars

Published In

Yale J Biol Med

ISSN

0044-0086

Publication Date

1989

Volume

62

Issue

6

Start / End Page

647 / 652

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Pemphigus
  • PUVA Therapy
  • Middle Aged
  • Male
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Extracorporeal Circulation
  • Autoimmune Diseases
 

Citation

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Rook, A. H., Heald, P. W., Nahass, G. T., Macey, W., Witmer, W. K., Lazarus, G. S., & Jegasothy, B. V. (1989). Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report. Yale J Biol Med, 62(6), 647–652.
Rook, A. H., P. W. Heald, G. T. Nahass, W. Macey, W. K. Witmer, G. S. Lazarus, and B. V. Jegasothy. “Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report.Yale J Biol Med 62, no. 6 (1989): 647–52.
Rook AH, Heald PW, Nahass GT, Macey W, Witmer WK, Lazarus GS, et al. Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report. Yale J Biol Med. 1989;62(6):647–52.
Rook, A. H., et al. “Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report.Yale J Biol Med, vol. 62, no. 6, 1989, pp. 647–52.
Rook AH, Heald PW, Nahass GT, Macey W, Witmer WK, Lazarus GS, Jegasothy BV. Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report. Yale J Biol Med. 1989;62(6):647–652.

Published In

Yale J Biol Med

ISSN

0044-0086

Publication Date

1989

Volume

62

Issue

6

Start / End Page

647 / 652

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Pemphigus
  • PUVA Therapy
  • Middle Aged
  • Male
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Extracorporeal Circulation
  • Autoimmune Diseases