Urokinase plasminogen activator is immunocytochemically detectable in squamous cell but not basal cell carcinomas.

Journal Article (Journal Article)

The presence of plasminogen activators (PA) in a variety of solid tumors appears to correlate, in a number of instances, with enhanced invasive or metastatic capabilities. In the present study, we have immunocytochemically examined basal cell (BCC) and squamous cell carcinomas (SCC) comprising a spectrum of histologic subtypes for the presence of urokinase-type (uPA) and tissue-type (tPA) PA. Neither uPA nor tPA was noted in any BCC, whether of the nodular, infiltrative, morpheaform, or basosquamous variety. uPA but not tPA was seen in 12 of 16 SCC examined; the tumors lacking uPA were all histologically well differentiated. No relationship between uPA expression and depth of invasion was noted, and uPA was not preferentially expressed at tumor borders. We conclude that uPA presence in SCC may relate to the degree of differentiation.

Full Text

Duke Authors

Cited Authors

  • Miller, SJ; Jensen, PJ; Dzubow, LM; Lazarus, GS

Published Date

  • March 1992

Published In

Volume / Issue

  • 98 / 3

Start / End Page

  • 351 - 358

PubMed ID

  • 1545144

International Standard Serial Number (ISSN)

  • 0022-202X

Digital Object Identifier (DOI)

  • 10.1111/1523-1747.ep12499803


  • eng

Conference Location

  • United States