Long-term results of radical perineal prostatectomy
The cancer-specific death rate following radical prostatectomy in patients with organ-confined and specimen-confined disease is 10% at 13.5 years, less than the noncancer death rate of 20% for patients in these disease extent categories. The median age of all patients in these categories was 65 years. Cancer remains the dominate cause of death in patients with margin-positive disease, being 40% at 13.5 years. Disease detected by prostate-specific antigen (PSA) rather than digital rectal examination appears to be of smaller volume and to have a higher probability of being margin negative. Data indicate that early detection by PSA will shift patients to a more favorable disease category at the time of surgical intervention. Disease recurrence or persistence by PSA detection seems to precede clinical detection of disease by 3-5 years. Disease recurrence by PSA detection does not predict survival outcome, probably does not differentiate between local and distant microscopic recurrence and is not predictive of biological aggressiveness.
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- Urology & Nephrology
- 1103 Clinical Sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Urology & Nephrology
- 1103 Clinical Sciences