Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

Published online

Journal Article

Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism. Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains. These observations provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism.

Full Text

Duke Authors

Cited Authors

  • Gupta, S; Ellis, SE; Ashar, FN; Moes, A; Bader, JS; Zhan, J; West, AB; Arking, DE

Published Date

  • December 10, 2014

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 5748 -

PubMed ID

  • 25494366

Pubmed Central ID

  • 25494366

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms6748

Language

  • eng

Conference Location

  • England