Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Publication
, Journal Article
Lee, BD; Shin, J-H; VanKampen, J; Petrucelli, L; West, AB; Ko, HS; Lee, Y-I; Maguire-Zeiss, KA; Bowers, WJ; Federoff, HJ; Dawson, VL; Dawson, TM
Published in: Nat Med
September 2010
Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.
Duke Scholars
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Published In
Nat Med
DOI
EISSN
1546-170X
Publication Date
September 2010
Volume
16
Issue
9
Start / End Page
998 / 1000
Location
United States
Related Subject Headings
- Protein Serine-Threonine Kinases
- Protein Kinase Inhibitors
- Phosphorylation
- Parkinson Disease
- Neurons
- Mutation
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Immunology
- Humans
- 42 Health sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, B. D., Shin, J.-H., VanKampen, J., Petrucelli, L., West, A. B., Ko, H. S., … Dawson, T. M. (2010). Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med, 16(9), 998–1000. https://doi.org/10.1038/nm.2199
Lee, Byoung Dae, Joo-Ho Shin, Jackalina VanKampen, Leonard Petrucelli, Andrew B. West, Han Seok Ko, Yun-Il Lee, et al. “Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.” Nat Med 16, no. 9 (September 2010): 998–1000. https://doi.org/10.1038/nm.2199.
Lee BD, Shin J-H, VanKampen J, Petrucelli L, West AB, Ko HS, et al. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med. 2010 Sep;16(9):998–1000.
Lee, Byoung Dae, et al. “Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.” Nat Med, vol. 16, no. 9, Sept. 2010, pp. 998–1000. Pubmed, doi:10.1038/nm.2199.
Lee BD, Shin J-H, VanKampen J, Petrucelli L, West AB, Ko HS, Lee Y-I, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med. 2010 Sep;16(9):998–1000.
Published In
Nat Med
DOI
EISSN
1546-170X
Publication Date
September 2010
Volume
16
Issue
9
Start / End Page
998 / 1000
Location
United States
Related Subject Headings
- Protein Serine-Threonine Kinases
- Protein Kinase Inhibitors
- Phosphorylation
- Parkinson Disease
- Neurons
- Mutation
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Immunology
- Humans
- 42 Health sciences