The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.

Journal Article (Journal Article)

Current treatments for Parkinson's disease fail to modify disease progression, and the underlying pathogenic mechanisms remain elusive. The identification of specific targets responsible for disease will aid in the development of relevant model systems and the discovery of neuroprotective and neurorestorative therapies. Two promising protein candidates, alpha-synuclein and LRRK2, offer unique insight into the molecular basis of disease and the potential to intervene in pathogenesis. Although multiple lines of evidence support alpha-synuclein and LRRK2 as robust targets for therapy, the connection between protein function and neurodegeneration is unclear. Technology capable of mitigating alpha-synuclein and LRRK2 disease-associated function will ultimately be required before the true value of these proteins as therapeutic targets can be discerned.

Full Text

Duke Authors

Cited Authors

  • Sen, S; West, AB

Published Date

  • September 2009

Published In

Volume / Issue

  • 11 / 9

Start / End Page

  • 2167 - 2187

PubMed ID

  • 19271991

Pubmed Central ID

  • PMC2787962

Electronic International Standard Serial Number (EISSN)

  • 1557-7716

Digital Object Identifier (DOI)

  • 10.1089/ars.2009.2430


  • eng

Conference Location

  • United States