The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.
Journal Article (Journal Article)
Current treatments for Parkinson's disease fail to modify disease progression, and the underlying pathogenic mechanisms remain elusive. The identification of specific targets responsible for disease will aid in the development of relevant model systems and the discovery of neuroprotective and neurorestorative therapies. Two promising protein candidates, alpha-synuclein and LRRK2, offer unique insight into the molecular basis of disease and the potential to intervene in pathogenesis. Although multiple lines of evidence support alpha-synuclein and LRRK2 as robust targets for therapy, the connection between protein function and neurodegeneration is unclear. Technology capable of mitigating alpha-synuclein and LRRK2 disease-associated function will ultimately be required before the true value of these proteins as therapeutic targets can be discerned.
Full Text
Duke Authors
Cited Authors
- Sen, S; West, AB
Published Date
- September 2009
Published In
Volume / Issue
- 11 / 9
Start / End Page
- 2167 - 2187
PubMed ID
- 19271991
Pubmed Central ID
- PMC2787962
Electronic International Standard Serial Number (EISSN)
- 1557-7716
Digital Object Identifier (DOI)
- 10.1089/ars.2009.2430
Language
- eng
Conference Location
- United States