Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.
Journal Article (Review)
The frequency and potency of mutations in the LRRK2 gene redefine the role of genetic susceptibility in Parkinson's disease. Dominant missense mutations that fulfill initial criteria for potential gain of function mechanisms coupled with enzymatic activity likely amenable to small molecule inhibition position LRRK2 as a promising therapeutic target. Herein, key observations from the clinic to the test tube are highlighted together with points of contention and outstanding critical issues. Resolution of the critical issues will expedite the development of therapies that exploit LRRK2 activity for neuroprotection strategies.
Full Text
Duke Authors
Cited Authors
- Biskup, S; West, AB
Published Date
- July 2009
Published In
Volume / Issue
- 1792 / 7
Start / End Page
- 625 - 633
PubMed ID
- 18973807
Pubmed Central ID
- 18973807
International Standard Serial Number (ISSN)
- 0006-3002
Digital Object Identifier (DOI)
- 10.1016/j.bbadis.2008.09.015
Language
- eng
Conference Location
- Netherlands