Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.

Journal Article (Review)

The frequency and potency of mutations in the LRRK2 gene redefine the role of genetic susceptibility in Parkinson's disease. Dominant missense mutations that fulfill initial criteria for potential gain of function mechanisms coupled with enzymatic activity likely amenable to small molecule inhibition position LRRK2 as a promising therapeutic target. Herein, key observations from the clinic to the test tube are highlighted together with points of contention and outstanding critical issues. Resolution of the critical issues will expedite the development of therapies that exploit LRRK2 activity for neuroprotection strategies.

Full Text

Duke Authors

Cited Authors

  • Biskup, S; West, AB

Published Date

  • July 2009

Published In

Volume / Issue

  • 1792 / 7

Start / End Page

  • 625 - 633

PubMed ID

  • 18973807

Pubmed Central ID

  • 18973807

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/j.bbadis.2008.09.015


  • eng

Conference Location

  • Netherlands