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alpha-Synuclein gene haplotypes are associated with Parkinson's disease.

Publication ,  Journal Article
Farrer, M; Maraganore, DM; Lockhart, P; Singleton, A; Lesnick, TG; de Andrade, M; West, A; de Silva, R; Hardy, J; Hernandez, D
Published in: Hum Mol Genet
August 15, 2001

We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

Duke Scholars

Published In

Hum Mol Genet

DOI

ISSN

0964-6906

Publication Date

August 15, 2001

Volume

10

Issue

17

Start / End Page

1847 / 1851

Location

England

Related Subject Headings

  • alpha-Synuclein
  • Synucleins
  • Sequence Analysis, Protein
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Parkinson Disease
  • Nerve Tissue Proteins
  • Mutation
  • Middle Aged
  • Male
 

Citation

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Farrer, M., Maraganore, D. M., Lockhart, P., Singleton, A., Lesnick, T. G., de Andrade, M., … Hernandez, D. (2001). alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Hum Mol Genet, 10(17), 1847–1851. https://doi.org/10.1093/hmg/10.17.1847
Farrer, M., D. M. Maraganore, P. Lockhart, A. Singleton, T. G. Lesnick, M. de Andrade, A. West, R. de Silva, J. Hardy, and D. Hernandez. “alpha-Synuclein gene haplotypes are associated with Parkinson's disease.Hum Mol Genet 10, no. 17 (August 15, 2001): 1847–51. https://doi.org/10.1093/hmg/10.17.1847.
Farrer M, Maraganore DM, Lockhart P, Singleton A, Lesnick TG, de Andrade M, et al. alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Hum Mol Genet. 2001 Aug 15;10(17):1847–51.
Farrer, M., et al. “alpha-Synuclein gene haplotypes are associated with Parkinson's disease.Hum Mol Genet, vol. 10, no. 17, Aug. 2001, pp. 1847–51. Pubmed, doi:10.1093/hmg/10.17.1847.
Farrer M, Maraganore DM, Lockhart P, Singleton A, Lesnick TG, de Andrade M, West A, de Silva R, Hardy J, Hernandez D. alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Hum Mol Genet. 2001 Aug 15;10(17):1847–1851.
Journal cover image

Published In

Hum Mol Genet

DOI

ISSN

0964-6906

Publication Date

August 15, 2001

Volume

10

Issue

17

Start / End Page

1847 / 1851

Location

England

Related Subject Headings

  • alpha-Synuclein
  • Synucleins
  • Sequence Analysis, Protein
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Parkinson Disease
  • Nerve Tissue Proteins
  • Mutation
  • Middle Aged
  • Male