alpha-Synuclein gene haplotypes are associated with Parkinson's disease.

Journal Article (Journal Article)

We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

Full Text

Duke Authors

Cited Authors

  • Farrer, M; Maraganore, DM; Lockhart, P; Singleton, A; Lesnick, TG; de Andrade, M; West, A; de Silva, R; Hardy, J; Hernandez, D

Published Date

  • August 15, 2001

Published In

Volume / Issue

  • 10 / 17

Start / End Page

  • 1847 - 1851

PubMed ID

  • 11532993

International Standard Serial Number (ISSN)

  • 0964-6906

Digital Object Identifier (DOI)

  • 10.1093/hmg/10.17.1847

Language

  • eng

Conference Location

  • England