alpha-Synuclein gene haplotypes are associated with Parkinson's disease.
Published
Journal Article
We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.
Full Text
Duke Authors
Cited Authors
- Farrer, M; Maraganore, DM; Lockhart, P; Singleton, A; Lesnick, TG; de Andrade, M; West, A; de Silva, R; Hardy, J; Hernandez, D
Published Date
- August 15, 2001
Published In
Volume / Issue
- 10 / 17
Start / End Page
- 1847 - 1851
PubMed ID
- 11532993
Pubmed Central ID
- 11532993
International Standard Serial Number (ISSN)
- 0964-6906
Digital Object Identifier (DOI)
- 10.1093/hmg/10.17.1847
Language
- eng
Conference Location
- England