alpha-Synuclein gene haplotypes are associated with Parkinson's disease.
We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.
Farrer, M; Maraganore, DM; Lockhart, P; Singleton, A; Lesnick, TG; de Andrade, M; West, A; de Silva, R; Hardy, J; Hernandez, D
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