Combination therapy with anti-HIV-1 antibodies maintains viral suppression.

Journal Article (Journal Article;Multicenter Study)

Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal anti-HIV-1 broadly neutralizing antibodies that target independent sites on the HIV-1 envelope spike, was administered during analytical treatment interruption. Participants received three infusions of 30 mg kg-1 of each antibody at 0, 3 and 6 weeks. Infusions of the two antibodies were generally well-tolerated. The nine enrolled individuals with antibody-sensitive latent viral reservoirs maintained suppression for between 15 and more than 30 weeks (median of 21 weeks), and none developed viruses that were resistant to both antibodies. We conclude that the combination of the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 can maintain long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Full Text

Duke Authors

Cited Authors

  • Mendoza, P; Gruell, H; Nogueira, L; Pai, JA; Butler, AL; Millard, K; Lehmann, C; Suárez, I; Oliveira, TY; Lorenzi, JCC; Cohen, YZ; Wyen, C; Kümmerle, T; Karagounis, T; Lu, C-L; Handl, L; Unson-O'Brien, C; Patel, R; Ruping, C; Schlotz, M; Witmer-Pack, M; Shimeliovich, I; Kremer, G; Thomas, E; Seaton, KE; Horowitz, J; West, AP; Bjorkman, PJ; Tomaras, GD; Gulick, RM; Pfeifer, N; Fätkenheuer, G; Seaman, MS; Klein, F; Caskey, M; Nussenzweig, MC

Published Date

  • September 2018

Published In

Volume / Issue

  • 561 / 7724

Start / End Page

  • 479 - 484

PubMed ID

  • 30258136

Pubmed Central ID

  • PMC6166473

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

Digital Object Identifier (DOI)

  • 10.1038/s41586-018-0531-2


  • eng

Conference Location

  • England