Linkage analysis in a family with the Opitz GBBB syndrome refines the location of the gene in Xp22 to a 4 cM region.


Journal Article

The Opitz GBBB syndrome (OS) is characterized in part by widely spaced inner ocular canthi and hypospadias. Recently, linkage analysis showed that the gene for the X-linked form to be located in an 18 cM region spanning Xp22. We have now conducted linkage analysis in a family previously published as having the BBB syndrome and found tight linkage to DXS7104 (Z = 3.3, theta = 0.0). Our data narrows the candidate region to 4 cM and should facilitate the identification and characterization of one of the genes involved in midline development.

Full Text

Cited Authors

  • May, M; Huston, S; Wilroy, RS; Schwartz, C

Published Date

  • January 1997

Published In

Volume / Issue

  • 68 / 2

Start / End Page

  • 244 - 248

PubMed ID

  • 9028470

Pubmed Central ID

  • 9028470

Electronic International Standard Serial Number (EISSN)

  • 1096-8628

International Standard Serial Number (ISSN)

  • 0148-7299

Digital Object Identifier (DOI)

  • 10.1002/(sici)1096-8628(19970120)68:2<244::aid-ajmg27>;2-t


  • eng