Neural basis of goal-driven changes in knowledge activation.

Journal Article (Journal Article)

Depending on a person's goals, different aspects of stored knowledge are accessed. Decades of behavioral work document the flexible use of knowledge, but little neuroimaging work speaks to these questions. We used representational similarity analysis to investigate whether the relationship between brain activity and semantic structure of statements varied in two tasks hypothesized to differ in the degree to which knowledge is accessed: judging truth (semantic task) and judging oldness (episodic task). During truth judgments, but not old/new recognition judgments, a left-lateralized network previously associated with semantic memory exhibited correlations with semantic structure. At a neural level, people activate knowledge representations in different ways when focused on different goals. The present results demonstrate the potential of multivariate approaches in characterizing knowledge storage and retrieval, as well as the ways that it shapes our understanding and long-term memory.

Full Text

Duke Authors

Cited Authors

  • Wang, W-C; Brashier, NM; Wing, EA; Marsh, EJ; Cabeza, R

Published Date

  • December 2018

Published In

Volume / Issue

  • 48 / 11

Start / End Page

  • 3389 - 3396

PubMed ID

  • 30290029

Pubmed Central ID

  • PMC6350035

Electronic International Standard Serial Number (EISSN)

  • 1460-9568

International Standard Serial Number (ISSN)

  • 0953-816X

Digital Object Identifier (DOI)

  • 10.1111/ejn.14196


  • eng