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Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge.

Publication ,  Journal Article
Puia-Dumitrescu, M; Bretzius, OM; Brown, N; Fitz-Henley, JA; Ssengonzi, R; Wechsler, CS; Gray, KD; Benjamin, DK; Smith, PB; Clark, RH ...
Published in: J Pediatr
December 2018

OBJECTIVE: To characterize the association between gentamicin dosing, duration of treatment, and ototoxicity in hospitalized infants. STUDY DESIGN: This retrospective cohort study conducted at 330 neonatal intensive care units (2002-2014) included inborn infants exposed to gentamicin with available hearing screen results, and excluded infants with incomplete dosing data and major congenital anomalies. Our primary outcome was the final hearing screen result performed during hospitalization: abnormal (failed or referred for further testing in one or both ears) or normal (bilateral passed). The 4 measures of gentamicin exposure were highest daily dose, average daily dose, cumulative dose, and cumulative duration of exposure. We fitted separate multivariable logistic regression models adjusted for demographics, comorbidities, and other clinical events. RESULTS: A total of 84 808 infants met inclusion/exclusion criteria; median (25th, 75th percentile) gestational age and birth weight were 35 weeks (33, 38) and 2480 g (1890, 3184), respectively. Failed hearing screens occurred in 3238 (3.8%) infants; failed screens were more likely in infants of lower gestational age and birth weight, who had longer hospital lengths of stay, higher rates of morbidities, and were small for gestational age. Median highest daily dose, average daily dose, and cumulative dose were 4.0 mg/kg/day (3.0, 4.0), 3.8 mg/kg/day (3.0, 4.0), and 12.1 mg/kg (9.1, 20.5), respectively. Median cumulative duration of exposure was 3 days (3, 6). In adjusted analysis, gentamicin dose and duration of therapy were not associated with hearing screen failure. CONCLUSIONS: Gentamicin dosing and duration of treatment were not associated with increased odds of failed hearing screen at the time of discharge from initial neonatal intensive care unit stay.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

December 2018

Volume

203

Start / End Page

131 / 136

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pediatrics
  • Patient Discharge
  • Neonatal Screening
  • Male
  • Length of Stay
  • Intensive Care Units, Neonatal
  • Infant, Small for Gestational Age
  • Infant, Newborn
  • Infant, Low Birth Weight
 

Citation

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Puia-Dumitrescu, M., Bretzius, O. M., Brown, N., Fitz-Henley, J. A., Ssengonzi, R., Wechsler, C. S., … Hornik, C. P. (2018). Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge. J Pediatr, 203, 131–136. https://doi.org/10.1016/j.jpeds.2018.07.101
Puia-Dumitrescu, Mihai, Olivia M. Bretzius, Nia Brown, James A. Fitz-Henley, Rebecca Ssengonzi, Caroline S. Wechsler, Keyaria D. Gray, et al. “Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge.J Pediatr 203 (December 2018): 131–36. https://doi.org/10.1016/j.jpeds.2018.07.101.
Puia-Dumitrescu M, Bretzius OM, Brown N, Fitz-Henley JA, Ssengonzi R, Wechsler CS, et al. Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge. J Pediatr. 2018 Dec;203:131–6.
Puia-Dumitrescu, Mihai, et al. “Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge.J Pediatr, vol. 203, Dec. 2018, pp. 131–36. Pubmed, doi:10.1016/j.jpeds.2018.07.101.
Puia-Dumitrescu M, Bretzius OM, Brown N, Fitz-Henley JA, Ssengonzi R, Wechsler CS, Gray KD, Benjamin DK, Smith PB, Clark RH, Gonzalez D, Hornik CP. Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge. J Pediatr. 2018 Dec;203:131–136.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

December 2018

Volume

203

Start / End Page

131 / 136

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pediatrics
  • Patient Discharge
  • Neonatal Screening
  • Male
  • Length of Stay
  • Intensive Care Units, Neonatal
  • Infant, Small for Gestational Age
  • Infant, Newborn
  • Infant, Low Birth Weight