Factors associated with 1-year mortality after discharge for acute stroke: what matters?

Journal Article (Journal Article)

OBJECTIVE: To evaluate factors associated with 1-year mortality after discharge for acute stroke. METHODS: In this retrospective cohort study, we studied 305 patients with ischemic stroke or intracerebral hemorrhage discharged in 2010/2011. We linked Get With The Guidelines®-Stroke clinical data with New York State administrative data and used multivariate regression models to examine variables related to 1-year all-cause mortality poststroke. RESULTS: The mean age was 68.6 ± 14.8 years and 51.1% were women. A total of 146 (47.9%) were discharged directly home, 96 (31.5%) to inpatient rehabilitation facilities (IRFs), and 63 (20.7%) to skilled nursing facilities (SNFs). Overall, 24 (7.9%) patients died within 1-year post-discharge. Older age (adjusted odds ratio [OR] 1.05, 95% confidence interval [CI] 1.00-1.10), higher National Institutes of Health Stroke Scale (NIHSS) on admission (OR 1.10, 95% CI 1.03-1.17), and discharge destination (IRF vs. home, OR 0.10, 95% CI 0.01-0.94; and SNF vs. home, OR 2.22, 95% CI 0.71-6.95) were factors associated with 1-year all-cause mortality. When ambulation status at discharge was added to the model, ambulation with assistance and non-ambulation were significantly associated with mortality (ambulatory with assistance vs. ambulatory, OR 9.42, 95% CI 1.87-47.61; nonambulatory vs. ambulatory, OR 12.65, 95% CI 1.89-84.89). CONCLUSIONS: While age and NIHSS on admission are important predictors of long-term outcomes, factors at discharge - ambulation status at discharge and discharge destination - are associated with 1-year mortality post-discharge for acute stroke and therefore could represent therapeutic targets to improve long-term survival in future studies.

Full Text

Duke Authors

Cited Authors

  • Magdon-Ismail, Z; Ledneva, T; Sun, M; Schwamm, LH; Sherman, B; Qian, F; Bettger, JP; Xian, Y; Stein, J

Published Date

  • December 2018

Published In

Volume / Issue

  • 25 / 8

Start / End Page

  • 576 - 583

PubMed ID

  • 30281414

Electronic International Standard Serial Number (EISSN)

  • 1945-5119

Digital Object Identifier (DOI)

  • 10.1080/10749357.2018.1499303


  • eng

Conference Location

  • England