Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe.

Journal Article (Journal Article)

Iclaprim is a diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and surveillance data prior to 2006 suggested that iclaprim was active against Gram-positive pathogens including emerging drug-resistant pathogens. In an era of increasing antimicrobial resistance, we undertook testing iclaprim and comparators against 931 Gram-positive clinical isolates from the United States and Europe collected between 2015 and 2016. Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Minimum inhibitory concentration (MIC) interpretations were based on CLSI and European Committee on Antimicrobial Susceptibility Testing criteria. MIC50/MIC90 was 0.03/0.12 for all Staphylococcus aureus, 0.06/0.06 for methicillin-susceptible S. aureus, 0.03/0.12 for methicillin-resistant S. aureus, 0.12/0.5 for Streptococcus agalactiae, ≤0.015/≤0.015 for Streptococcus anginosus, 0.03/0.06 for Streptococcus dysgalactiae, and ≤0.015 /0.03 μg/mL for Streptococcus pyogenes. Iclaprim was active against a contemporary collection (2015-2016) of Gram-positive bacteria isolated from the skin or soft tissue from patients with SSSI from the United States and Europe.

Full Text

Duke Authors

Cited Authors

  • Huang, DB; Magnet, S; De Angelis, S; Holland, TL; File, TM; Dryden, M; Corey, GR; Torres, A; Wilcox, MH

Published Date

  • February 2019

Published In

Volume / Issue

  • 93 / 2

Start / End Page

  • 154 - 158

PubMed ID

  • 30266399

Electronic International Standard Serial Number (EISSN)

  • 1879-0070

Digital Object Identifier (DOI)

  • 10.1016/j.diagmicrobio.2018.09.002


  • eng

Conference Location

  • United States